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An efficient synthesis of 2-amino-3-cyano-2-pyrrolin-4-ones, via the corresponding open chain tautomers (aminoacetylmalononitriles)

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dc.contributor.author Hamilakis, S en
dc.contributor.author Tsolomitis, A en
dc.date.accessioned 2014-03-01T01:18:38Z
dc.date.available 2014-03-01T01:18:38Z
dc.date.issued 2003 en
dc.identifier.issn 0040-4039 en
dc.identifier.uri http://hdl.handle.net/123456789/15122
dc.subject 2-amino-3-cyano-2-pyrrolin-4-ones en
dc.subject Aminoacetylmalononitriles en
dc.subject CDI en
dc.subject Tautomers en
dc.subject.classification Chemistry, Organic en
dc.subject.other 2 amino 3 cyano 2 pyrrolin 4 one en
dc.subject.other amino acid en
dc.subject.other aminoacetonitrile en
dc.subject.other aminoacetylmalononitrile en
dc.subject.other carbene en
dc.subject.other carbonyl derivative en
dc.subject.other carbonyl diimidazole en
dc.subject.other chemical compound en
dc.subject.other enol en
dc.subject.other glycine derivative en
dc.subject.other imidazole derivative en
dc.subject.other malononitrile en
dc.subject.other prodrug en
dc.subject.other unclassified drug en
dc.subject.other acylation en
dc.subject.other article en
dc.subject.other chemical parameters en
dc.subject.other chemical procedures en
dc.subject.other drug synthesis en
dc.subject.other isolation procedure en
dc.title An efficient synthesis of 2-amino-3-cyano-2-pyrrolin-4-ones, via the corresponding open chain tautomers (aminoacetylmalononitriles) en
heal.type journalArticle en
heal.identifier.primary 10.1016/S0040-4039(03)00730-5 en
heal.identifier.secondary http://dx.doi.org/10.1016/S0040-4039(03)00730-5 en
heal.language English en
heal.publicationDate 2003 en
heal.abstract Malononitrile has been found to be acylated effectively using N-protected glycines by simultaneous activation of an amino acid carbonyl group and a malononitrile methylene group using carbonyl diimidazole (CDI). The corresponding aminoacetonitriles were isolated as enols and/or as their tautomeric forms, 2-amino-3-cyano-2-pyrrolin-4-ones. (C) 2003 Elsevier Science Ltd. All rights reserved. en
heal.publisher PERGAMON-ELSEVIER SCIENCE LTD en
heal.journalName Tetrahedron Letters en
dc.identifier.doi 10.1016/S0040-4039(03)00730-5 en
dc.identifier.isi ISI:000182573300022 en
dc.identifier.volume 44 en
dc.identifier.issue 19 en
dc.identifier.spage 3821 en
dc.identifier.epage 3823 en


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