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Nucleophilic Ring Enlargement of 2-Substituted-3-isothiazolones to 1,3-Thiazin-4-ones

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dc.contributor.author Hamilakis, S en
dc.contributor.author Tsolomitis, A en
dc.date.accessioned 2014-03-01T01:19:20Z
dc.date.available 2014-03-01T01:19:20Z
dc.date.issued 2003 en
dc.identifier.issn 0039-7911 en
dc.identifier.uri http://hdl.handle.net/123456789/15433
dc.subject 1,3-Thiazin-4-ones en
dc.subject 3-Isothiazolones en
dc.subject Nucleophilic ring expansion en
dc.subject Two phase reactions en
dc.subject.classification Chemistry, Organic en
dc.subject.other 1,3 thiazin 4 one derivative en
dc.subject.other 1,3 thiazine derivative en
dc.subject.other 3 isothiazolone derivative en
dc.subject.other amine en
dc.subject.other isothiazolone derivative en
dc.subject.other nitrogen en
dc.subject.other sulfur en
dc.subject.other thiazole derivative en
dc.subject.other unclassified drug en
dc.subject.other aqueous solution en
dc.subject.other article en
dc.subject.other chemical analysis en
dc.subject.other chemical bond en
dc.subject.other chemical reaction en
dc.subject.other conformational transition en
dc.subject.other dissociation en
dc.subject.other drug conformation en
dc.subject.other drug structure en
dc.subject.other drug synthesis en
dc.subject.other infrared spectroscopy en
dc.subject.other proton nuclear magnetic resonance en
dc.subject.other proton transport en
dc.subject.other reaction analysis en
dc.subject.other room temperature en
dc.subject.other structure analysis en
dc.subject.other substitution reaction en
dc.subject.other technique en
dc.title Nucleophilic Ring Enlargement of 2-Substituted-3-isothiazolones to 1,3-Thiazin-4-ones en
heal.type journalArticle en
heal.identifier.primary 10.1081/SCC-120026864 en
heal.identifier.secondary http://dx.doi.org/10.1081/SCC-120026864 en
heal.language English en
heal.publicationDate 2003 en
heal.abstract 1,3-Thiazin-4-ones 9 and 10 have been prepared from the corresponding isothiazolones 7 and 8 by a clean and smooth reaction with tertiary amines at room temperature. This rearrangement is attributed to the abstraction of a methine proton from the 2-position isothiazolone substituent, followed by ring enlargement through cleavage of the S-N bond. en
heal.publisher MARCEL DEKKER INC en
heal.journalName Synthetic Communications en
dc.identifier.doi 10.1081/SCC-120026864 en
dc.identifier.isi ISI:000187532900020 en
dc.identifier.volume 33 en
dc.identifier.issue 24 en
dc.identifier.spage 4339 en
dc.identifier.epage 4345 en


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