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Psychophysiological evidence for altered information processing in delusional misidentification syndromes

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dc.contributor.author Papageorgiou, C en
dc.contributor.author Ventouras, E en
dc.contributor.author Lykouras, L en
dc.contributor.author Uzunoglu, N en
dc.contributor.author Christodoulou, GN en
dc.date.accessioned 2014-03-01T01:19:27Z
dc.date.available 2014-03-01T01:19:27Z
dc.date.issued 2003 en
dc.identifier.issn 0278-5846 en
dc.identifier.uri http://hdl.handle.net/123456789/15506
dc.subject Capgras syndrome en
dc.subject Delusional misidentification syndromes en
dc.subject Event-related potentials en
dc.subject Frégoli syndrome en
dc.subject P300 en
dc.subject Working memory en
dc.subject.classification Clinical Neurology en
dc.subject.classification Neurosciences en
dc.subject.classification Pharmacology & Pharmacy en
dc.subject.classification Psychiatry en
dc.subject.other adult en
dc.subject.other age en
dc.subject.other article en
dc.subject.other brain region en
dc.subject.other clinical article en
dc.subject.other cognitive defect en
dc.subject.other controlled study en
dc.subject.other delusion en
dc.subject.other education en
dc.subject.other event related potential en
dc.subject.other evoked auditory response en
dc.subject.other female en
dc.subject.other gray matter en
dc.subject.other human en
dc.subject.other information processing en
dc.subject.other male en
dc.subject.other patient en
dc.subject.other psychophysiology en
dc.subject.other sex en
dc.subject.other working memory en
dc.subject.other Adult en
dc.subject.other Analysis of Variance en
dc.subject.other Evoked Potentials, Auditory en
dc.subject.other Female en
dc.subject.other Humans en
dc.subject.other Logistic Models en
dc.subject.other Male en
dc.subject.other Mental Processes en
dc.subject.other Schizophrenia, Paranoid en
dc.subject.other Statistics, Nonparametric en
dc.title Psychophysiological evidence for altered information processing in delusional misidentification syndromes en
heal.type journalArticle en
heal.identifier.primary 10.1016/S0278-5846(02)00353-6 en
heal.identifier.secondary http://dx.doi.org/10.1016/S0278-5846(02)00353-6 en
heal.language English en
heal.publicationDate 2003 en
heal.abstract Recent research provides evidence that delusional misidentification syndromes (DMS) are associated with cognitive deficits. However, the underlying mechanisms of these deficits are not known. Since the P300 component of event-related potentials (ERPs) is related to fundamental aspects of working memory (WM), the present study is focused on P300 elicited during a WM test in DMS patients, as compared to those of healthy controls. Nine patients with DMS and 11 healthy controls, matched for age, sex and educational level were tested with a computerized version of the digit span test of the Wechsler batteries. Auditory ERPs were measured during the anticipatory period of the test. DMS patients showed significant reductions in P300 amplitude at the right frontal region compared to healthy controls. P300 latency in the central midline brain region was significantly prolonged in the DMS group. Each of these measures classified correctly 90% of the two groups. Moreover, the memory performance of the patient group was significantly lower, relatively to healthy controls. These findings provide evidence supporting the suggestion that DMS is associated with psychophysiological alterations occurring at the right frontal region, which mediates automatic processes, as well as with an irregular allocation of attentional resources, involving the interhemispheric circuitry, possibly due to gray matter degeneration. Finally, present work points to a need for further research investigating the characteristics, causes, course and treatment of severe cognitive deficits associated with DMS. (C) 2002 Elsevier Science Inc. All rights reserved. en
heal.publisher PERGAMON-ELSEVIER SCIENCE LTD en
heal.journalName Progress in Neuro-Psychopharmacology and Biological Psychiatry en
dc.identifier.doi 10.1016/S0278-5846(02)00353-6 en
dc.identifier.isi ISI:000182462600004 en
dc.identifier.volume 27 en
dc.identifier.issue 3 en
dc.identifier.spage 365 en
dc.identifier.epage 372 en


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