Local hemodynamics and intimal hyperplasia at the venous side of a porcine arteriovenous shunt

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dc.contributor.author Manos, TA en
dc.contributor.author Sokolis, DP en
dc.contributor.author Giagini, AT en
dc.contributor.author Davos, CH en
dc.contributor.author Kakisis, JD en
dc.contributor.author Kritharis, EP en
dc.contributor.author Stergiopulos, N en
dc.contributor.author Karayannacos, PE en
dc.contributor.author Tsangaris, S en
dc.date.accessioned 2014-03-01T01:33:42Z
dc.date.available 2014-03-01T01:33:42Z
dc.date.issued 2010 en
dc.identifier.issn 1089-7771 en
dc.identifier.uri http://hdl.handle.net/123456789/20546
dc.subject Arteriovenous shunt en
dc.subject Computational fluid dynamics en
dc.subject Doppler ultrasound en
dc.subject Hemodynamics en
dc.subject Intimal hyperplasia en
dc.subject Swine model en
dc.subject.classification Computer Science, Information Systems en
dc.subject.classification Computer Science, Interdisciplinary Applications en
dc.subject.classification Mathematical & Computational Biology en
dc.subject.classification Medical Informatics en
dc.subject.other Arteriovenous shunt en
dc.subject.other Biplane angiographies en
dc.subject.other Color Doppler en
dc.subject.other Computational model en
dc.subject.other Dean vortex en
dc.subject.other Doppler ultrasound en
dc.subject.other Experimental data en
dc.subject.other In-vivo en
dc.subject.other In-vivo experiments en
dc.subject.other Input datas en
dc.subject.other Intimal hyperplasia en
dc.subject.other Intravascular en
dc.subject.other Mechanical study en
dc.subject.other Transition lines en
dc.subject.other Ultrasound measurement en
dc.subject.other Vessel walls en
dc.subject.other Wall mechanics en
dc.subject.other Wall shear stress en
dc.subject.other WSS gradients en
dc.subject.other Computational fluid dynamics en
dc.subject.other Flow fields en
dc.subject.other Fluid dynamics en
dc.subject.other Fluids en
dc.subject.other Hydrodynamics en
dc.subject.other Non Newtonian flow en
dc.subject.other Stresses en
dc.subject.other Ultrasonics en
dc.subject.other Unsteady flow en
dc.subject.other Hemodynamics en
dc.title Local hemodynamics and intimal hyperplasia at the venous side of a porcine arteriovenous shunt en
heal.type journalArticle en
heal.identifier.primary 10.1109/TITB.2010.2040288 en
heal.identifier.secondary http://dx.doi.org/10.1109/TITB.2010.2040288 en
heal.identifier.secondary 5438787 en
heal.language English en
heal.publicationDate 2010 en
heal.abstract Venous anastomotic intimal hyperplasia (IH) observed in the arteriovenous shunt (AVS) has been associated with disturbed hemodynamics. This study aims to correlate hemodynamics with wall histology and wall mechanics by examining the flow field in AVS with computational fluid dynamics using experimental data taken from in vivo experiments. Input data to the computational model were obtained in vivo one month after AVS creation; adjacent vessels were submitted to histological and mechanical examination. The 3-D shunt geometry was determined using biplane angiography. Ultrasound measurements of flow rates were performed with perivascular flow probes and pressures were recorded through intravascular catheters. These data were considered as boundary conditions for calculation of the unsteady flow field. Numerical findings are suggestive of strong Dean vortices toward bothveinflowexits, verified by color Doppler. The high wall shear stresses (WSSs) and their gradients appear to be related to areas of IH and vessel wall stiffening, as evidenced in preliminary histological and mechanical studies of the venous wall. Additionally, suture line hyperplasia seems to be aggravated by the high WSS gradients noted at the transition line from graft to vein. © 2006 IEEE. en
heal.journalName IEEE Transactions on Information Technology in Biomedicine en
dc.identifier.doi 10.1109/TITB.2010.2040288 en
dc.identifier.isi ISI:000278538300017 en
dc.identifier.volume 14 en
dc.identifier.issue 3 en
dc.identifier.spage 681 en
dc.identifier.epage 690 en

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