HEAL DSpace

Photodynamic treatment of pancreatic cancer cells: Genotoxicity and chromosome damage induced by red light and zinc tetrasulfonated phthalocyanines (ZnPcS4)

DSpace/Manakin Repository

Show simple item record

dc.contributor.author Halkiotis Konstantinos, N en
dc.contributor.author Yova Dido, K en
dc.contributor.author Pantelias Gabriel, E en
dc.date.accessioned 2014-03-01T01:48:42Z
dc.date.available 2014-03-01T01:48:42Z
dc.date.issued 1999 en
dc.identifier.issn 0277786X en
dc.identifier.uri http://hdl.handle.net/123456789/25565
dc.relation.uri http://www.scopus.com/inward/record.url?eid=2-s2.0-0032659207&partnerID=40&md5=4529a91860d19be742389f8f6b634228 en
dc.subject.other Cytology en
dc.subject.other Drug products en
dc.subject.other Genes en
dc.subject.other Laser tissue interaction en
dc.subject.other Oncology en
dc.subject.other Photodynamic therapy en
dc.subject.other Semiconductor lasers en
dc.subject.other Toxicity en
dc.subject.other Zinc compounds en
dc.subject.other Genotoxicity en
dc.subject.other Zinc tetrasulfonated phthalocyanine en
dc.subject.other Biomedical engineering en
dc.title Photodynamic treatment of pancreatic cancer cells: Genotoxicity and chromosome damage induced by red light and zinc tetrasulfonated phthalocyanines (ZnPcS4) en
heal.type journalArticle en
heal.publicationDate 1999 en
heal.abstract PDT relies on the combined action of photosensitizers localized on tumours and activated under laser light. Tumour cells response to PDT is determined by both the photosensitizer and the photoirradiation dose. However, the processes governing the resultant tumour destruction are still unknown and recent advances in the field of cellular biology have stimulated the research interest in this field. In this paper, the genotoxicity and chromosome damage on MIA pancreatic cancer cells, induced by red light and zinc tetrasulfonated phthalocyanines (ZnPcS4) was studied. The results showed that cells treated with a low concentration (1 μM) of ZnPcS4 and a light dose of 6 J/cm2 indicated more than 70% lethality, 72 hrs after irradiation. The SCE assay, showed that treated cells with various light and drug doses, presented no genotoxic potential, as far as SCE levels were not different from those of the untreated (control) cells. Chromosomal analysis after optimum PDT treatment in various time intervals post irradiation, showed that there was not any significant chromosomal damage on cells, compared to the untreated (control) cells. en
heal.publisher Society of Photo-Optical Instrumentation Engineers, Bellingham, WA, United States en
heal.journalName Proceedings of SPIE - The International Society for Optical Engineering en
dc.identifier.volume 3563 en
dc.identifier.spage 38 en
dc.identifier.epage 49 en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record