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Photoinduced effect of hypericin on collagen and tissues with high collagen content

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dc.contributor.author Yova, D en
dc.contributor.author Theodossiou, T en
dc.contributor.author Hovhannisyan, V en
dc.date.accessioned 2014-03-01T01:48:42Z
dc.date.available 2014-03-01T01:48:42Z
dc.date.issued 1999 en
dc.identifier.issn 0277786X en
dc.identifier.uri http://hdl.handle.net/123456789/25566
dc.relation.uri http://www.scopus.com/inward/record.url?eid=2-s2.0-0032631382&partnerID=40&md5=f29a1616f63209b2084489a37ab3927d en
dc.subject.other Collagen en
dc.subject.other Fluorescence en
dc.subject.other Second harmonic generation en
dc.subject.other Solid state lasers en
dc.subject.other Tissue en
dc.subject.other Hypericin en
dc.subject.other Polycyclic quinone en
dc.subject.other Laser tissue interaction en
dc.title Photoinduced effect of hypericin on collagen and tissues with high collagen content en
heal.type journalArticle en
heal.publicationDate 1999 en
heal.abstract The photoinduced effect of hypericin, a polycyclic quinone, on collagen has been investigated. It was found that after laser irradiation at both 532 nm and 337 nm, the spectral form of triple helix structure collagen fluorescence, changed to a spectral profile bearing resemblance to that of its polypeptide single chain counterpart, gelatin, or heated collagen. The effect of Chlorin e6 on collagen was also investigated and proved to be dissimilar to that of hypericin and not indicative of profound structural alterations. Second Harmonic Generation (SHG) of 1064 nm-nanosecond laser radiation in collagen was studied. While it was very efficient for pure collagen, the signal intensity was found to diminish by at least an order of magnitude after hypericin photosensitization or heating. The above noted fluorescence spectral form alteration was also observed in a smaller scale in collagen rich chicken tissue (tendon). Non sensitized chicken tendon tissue exhibited very efficient SHG, unlike skin and artery samples. en
heal.publisher Society of Photo-Optical Instrumentation Engineers, Bellingham, WA, United States en
heal.journalName Proceedings of SPIE - The International Society for Optical Engineering en
dc.identifier.volume 3565 en
dc.identifier.spage 174 en
dc.identifier.epage 180 en


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