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Rapidly Progressive Dementia Causes Found in a Greek Tertiary Referral Center in Athens

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dc.contributor.author Papageorgiou, SG en
dc.contributor.author Kontaxis, T en
dc.contributor.author Bonakis, A en
dc.contributor.author Karahalios, G en
dc.contributor.author Kalfakis, N en
dc.contributor.author Vassilopoulos, D en
dc.date.accessioned 2014-03-01T01:58:57Z
dc.date.available 2014-03-01T01:58:57Z
dc.date.issued 2009 en
dc.identifier.issn 0893-0341 en
dc.identifier.uri http://hdl.handle.net/123456789/28791
dc.subject dementia en
dc.subject rapidly progressive dementias en
dc.subject spongiform encephalopathy en
dc.subject secondary dementias en
dc.subject treatable dementias en
dc.subject.classification Clinical Neurology en
dc.subject.classification Pathology en
dc.subject.other CREUTZFELDT-JAKOB-DISEASE en
dc.subject.other MULTIPLE SYSTEM ATROPHY en
dc.subject.other MOTOR-NEURON DISEASE en
dc.subject.other ALZHEIMERS-DISEASE en
dc.subject.other INTERNATIONAL WORKSHOP en
dc.subject.other DIAGNOSTIC-CRITERIA en
dc.subject.other CLINICAL-DIAGNOSIS en
dc.subject.other FRONTOTEMPORAL DEMENTIA en
dc.subject.other CEREBROSPINAL-FLUID en
dc.subject.other VASCULAR DEMENTIA en
dc.title Rapidly Progressive Dementia Causes Found in a Greek Tertiary Referral Center in Athens en
heal.type journalArticle en
heal.language English en
heal.publicationDate 2009 en
heal.abstract Dementia is generally considered as rapidly progressive [rapidly progressive dementia (RPD)], in cases with overt cognitive impairment, established within months. Data about the relative frequency of underlying diseases in cases of RPD are few and extremely variable, depending on the clinical setting. We examined the relative frequency of the underlying causes of RPD, in a university tertiary referral center, in Athens. A series of consecutive patients presenting with RPD in a 3-year period was included. All patients received a comprehensive clinical, imaging, and laboratory evaluation. Of a total of 279 patients hospitalized for dementia diagnosis, 68 patients had RPD (37 males and 31 females). Mean age at onset +/- SD was 65.5 +/- 10.0. The most common cause of RPD was secondary dementias, accounting for 18 cases (26.5%). Alzheimer disease and frontotemporal dementia were almost equally represented, accounting for 12 (17.6%) and 11 (16.2%) cases, respectively. Vascular dementia, Creutzfeldt-Jakob disease, and various neurodegenerative diseases accounted for 9 cases each (13.2%). In a tertiary referral center, secondary dementias represented the most frequent cause of cases presenting with RPD. As a substantial number of these cases are potentially treatable, our finding reconfirms and underscores the importance of an exhaustive evaluation in any case presenting with RPD. en
heal.publisher LIPPINCOTT WILLIAMS & WILKINS en
heal.journalName ALZHEIMER DISEASE & ASSOCIATED DISORDERS en
dc.identifier.isi ISI:000272403700007 en
dc.identifier.volume 23 en
dc.identifier.issue 4 en
dc.identifier.spage 337 en
dc.identifier.epage 346 en


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