Maximizing the benefits of screening mammography for women 40-49 years old

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dc.contributor.author Bastardis-Zakas, K en
dc.contributor.author Iatrakis, G en
dc.contributor.author Navrozoglou, I en
dc.contributor.author Peitsidis, P en
dc.contributor.author Salakos, N en
dc.contributor.author Malakassis, P en
dc.contributor.author Zervoudis, S en
dc.date.accessioned 2014-03-01T01:59:44Z
dc.date.available 2014-03-01T01:59:44Z
dc.date.issued 2010 en
dc.identifier.issn 03906663 en
dc.identifier.uri http://hdl.handle.net/123456789/29032
dc.relation.uri http://www.scopus.com/inward/record.url?eid=2-s2.0-78650263212&partnerID=40&md5=9773c8b1c8d31cb033e7410254bc6c04 en
dc.subject Mammography before 50 years old en
dc.subject Mammography in young women en
dc.subject Screening mammography en
dc.subject.other aging en
dc.subject.other article en
dc.subject.other breast cancer en
dc.subject.other cancer mortality en
dc.subject.other clinical trial en
dc.subject.other groups by age en
dc.subject.other human en
dc.subject.other mammography en
dc.subject.other meta analysis en
dc.subject.other mortality en
dc.subject.other screening en
dc.subject.other statistical significance en
dc.subject.other systematic review en
dc.subject.other Adult en
dc.subject.other Age Factors en
dc.subject.other Breast Neoplasms en
dc.subject.other Female en
dc.subject.other Humans en
dc.subject.other Mammography en
dc.subject.other Mass Screening en
dc.subject.other Meta-Analysis as Topic en
dc.subject.other Middle Aged en
dc.subject.other Randomized Controlled Trials as Topic en
dc.subject.other Risk en
dc.title Maximizing the benefits of screening mammography for women 40-49 years old en
heal.type journalArticle en
heal.publicationDate 2010 en
heal.abstract Background: While women aged 50 and older are broadly considered to benefit from screening mammograms, the evidence of any similar advantages for younger women are still considered insufficient to form any substantial conclusions on the matter. The primary goal of this study was to examine whether or not the mortality rate of younger women is benefited by mammography, and if so, how can this beneficial effect be maximized. Methods: The authors have taken into account all available randomized control trials (RCTs) and have conducted a meta-analysis based on those RCTs to study the effect of mammography on the mortality rate of women younger than age 50. Further interpretation on various aspects of the results has also led to separate meta-analyses, with the RCTs included grouped in accordance to the mean time interval between screening mammograms employed by each study. The findings and conclusions of the comparison were used to calculate the number of mammograms necessary to reduce the absolute death risk, depending on the time interval between screening mammograms. Results: The meta-analysis indicated a reduction in breast-cancer mortality in the intervention group, which reached statistical significance (relative risk (RR) 0.81 [95% CI 0.71-0.93] p < 0.01). Furthermore, when the RCTs included were grouped according to their mean time interval between mammograms, there was a definite increase of statistical significance in favor of those RCTs with shorter interval times (RR 0.76 [95% CI 0.64-0.89] p < 0.01). Conclusions: The significant mortality rate reduction demonstrated by the meta-analytical results is a key indicator of the beneficial effect of mammography on the age group of women younger than 50. Additionally, the increase in the aforesaid significance when combining RCTs with short time intervals between mammograms, as opposed to those RCTs with longer intervals, suggests that the optimal use of mammographic screening lies with the former. This is better demonstrated when taking in account our approach to answering the practical question of ""how many screening mammograms will take to save one life?"" in correlation with the mean time interval involved. en
heal.journalName Clinical and Experimental Obstetrics and Gynecology en
dc.identifier.volume 37 en
dc.identifier.issue 4 en
dc.identifier.spage 278 en
dc.identifier.epage 282 en

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