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Multi-responsive polymeric microcontainers for potential biomedical applications: Synthesis and functionality evaluation

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dc.contributor.author Bilalis, P en
dc.contributor.author Efthimiadou, EK en
dc.contributor.author Chatzipavlidis, A en
dc.contributor.author Boukos, N en
dc.contributor.author Kordas, GC en
dc.date.accessioned 2014-03-01T02:11:28Z
dc.date.available 2014-03-01T02:11:28Z
dc.date.issued 2012 en
dc.identifier.issn 09598103 en
dc.identifier.uri http://hdl.handle.net/123456789/29917
dc.subject Daunorubicin en
dc.subject Distillation precipitation polymerization en
dc.subject Magnetic nanoparticles en
dc.subject Microcontainers en
dc.subject PH sensitive en
dc.subject Thermosensitive en
dc.subject.other Daunorubicin en
dc.subject.other Distillation-precipitation polymerization en
dc.subject.other Magnetic nanoparticles en
dc.subject.other Microcontainers en
dc.subject.other pH sensitive en
dc.subject.other Thermo sensitive en
dc.subject.other Acrylic monomers en
dc.subject.other Catalyst activity en
dc.subject.other Distillation en
dc.subject.other Fourier transform infrared spectroscopy en
dc.subject.other Functional polymers en
dc.subject.other Magnetic properties en
dc.subject.other Medical applications en
dc.subject.other Nanoparticles en
dc.subject.other Polymerization en
dc.subject.other Scanning electron microscopy en
dc.subject.other Ultraviolet visible spectroscopy en
dc.subject.other X ray diffraction en
dc.subject.other Synthesis (chemical) en
dc.title Multi-responsive polymeric microcontainers for potential biomedical applications: Synthesis and functionality evaluation en
heal.type journalArticle en
heal.identifier.primary 10.1002/pi.4152 en
heal.identifier.secondary http://dx.doi.org/10.1002/pi.4152 en
heal.publicationDate 2012 en
heal.abstract Temperature and pH responsive poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAAm-co-MAA)) microcontainers with encapsulated magnetic nanoparticles in the shell were prepared by a two-stage distillation precipitation polymerization. PMAA@Fe3O4/P(NIPAAm-co-MAA) core-shell nanoparticles were synthesized by the second-stage polymerization of NIPAAm, MAA and N, N′-methylenebisacrylamide as crosslinker in the presence of magnetic nanoparticles and PMAA as core. These novel triple-functional microcontainers were prepared by selective removal of the PMAA core in water. Daunorubicin hydrochloride (DNR) was loaded into the microcontainers and the release profile was studied by UV-visible spectroscopy. The synthesized nanostructures were characterized with transmission and scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The magnetic properties were evaluated by vibrating sample magnetometry. The shrink and swelling behavior was studied by dynamic light scattering. © 2012 Society of Chemical Industry. en
heal.journalName Polymer International en
dc.identifier.doi 10.1002/pi.4152 en
dc.identifier.volume 61 en
dc.identifier.issue 6 en
dc.identifier.spage 888 en
dc.identifier.epage 894 en


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