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Optimizing multienzyme production

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dc.contributor.author Hatzinikolaou, DG en
dc.contributor.author Macris, BJ en
dc.date.accessioned 2014-03-01T02:40:57Z
dc.date.available 2014-03-01T02:40:57Z
dc.date.issued 1992 en
dc.identifier.issn 0077-8923 en
dc.identifier.uri http://hdl.handle.net/123456789/30293
dc.relation.uri http://www.scopus.com/inward/record.url?eid=2-s2.0-0027056285&partnerID=40&md5=f075d9620b4a7f1bff1e709e5741a4ee en
dc.subject.classification Multidisciplinary Sciences en
dc.subject.other carbon en
dc.subject.other catalase en
dc.subject.other glucose oxidase en
dc.subject.other nitrogen en
dc.subject.other superoxide dismutase en
dc.subject.other aspergillus niger en
dc.subject.other conference paper en
dc.subject.other cost en
dc.subject.other enzyme activity en
dc.subject.other enzyme assay en
dc.subject.other enzyme purification en
dc.subject.other enzyme synthesis en
dc.subject.other fermentation en
dc.subject.other fungus growth en
dc.subject.other model en
dc.subject.other nonhuman en
dc.subject.other priority journal en
dc.title Optimizing multienzyme production en
heal.type conferenceItem en
heal.language English en
heal.publicationDate 1992 en
heal.abstract The possibility of optimizing certain fermentation conditions towards the total unit productivity of several enzymes has been investigated. As a model system, we used a particular strain of Aspergillus niger capable of simultaneously producing significant levels of superoxide dismutase, glucose oxidase, and catalase. The fermentation parameters used in the optimization were the fermentation time, and the concentration of carbon and nitrogen source. The optimum set of fermentation parameters for maximum production of each enzyme has initially been determined. The introduction of a value factor for each enzyme unit of specific purity yields the conclusion that there is a point in the parameter space, different from that of optimum production of each separate enzyme, where a maximum exists for the total unit value of the three enzymes produced. This result suggests that multienzyme optimization in fermentations may effectively reduce the cost of the production process. en
heal.publisher NEW YORK ACAD SCIENCES en
heal.journalName Annals of the New York Academy of Sciences en
dc.identifier.isi ISI:A1992KJ58500083 en
dc.identifier.volume 672 en
dc.identifier.spage 595 en
dc.identifier.epage 602 en


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