Web service-enabled grid-based platform for drug resistance management

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dc.contributor.author Gouvas, P en
dc.contributor.author Magiorkinis, G en
dc.contributor.author Bouras, A en
dc.contributor.author Paraskevis, D en
dc.contributor.author Alexandrou, D en
dc.contributor.author Hatzakis, A en
dc.contributor.author Mentzas, G en
dc.date.accessioned 2014-03-01T02:43:46Z
dc.date.available 2014-03-01T02:43:46Z
dc.date.issued 2005 en
dc.identifier.issn 0302-9743 en
dc.identifier.uri http://hdl.handle.net/123456789/31503
dc.subject Clinical Practice en
dc.subject Design and Development en
dc.subject Drug Resistance en
dc.subject Experimental Procedure en
dc.subject Hiv Drug Resistance en
dc.subject Multiple Sequence Alignment en
dc.subject Nucleotide Sequence en
dc.subject Phylogenetic Analysis en
dc.subject Research Purpose en
dc.subject Software Component en
dc.subject Web Service en
dc.subject.classification Computer Science, Theory & Methods en
dc.subject.other Algorithms en
dc.subject.other Error analysis en
dc.subject.other Estimation en
dc.subject.other Information services en
dc.subject.other Mutagenesis en
dc.subject.other World Wide Web en
dc.subject.other Genotypic resistance interpretation en
dc.subject.other Mutation identification en
dc.subject.other Phylogenetic analysis en
dc.subject.other Web services en
dc.subject.other Distributed computer systems en
dc.title Web service-enabled grid-based platform for drug resistance management en
heal.type conferenceItem en
heal.identifier.primary 10.1007/11573036_44 en
heal.identifier.secondary http://dx.doi.org/10.1007/11573036_44 en
heal.language English en
heal.publicationDate 2005 en
heal.abstract HIV Drug Resistance testing has been established as a routine test in several cases. Estimation of genotypic resistance is a laborious task consisting of experimental procedure and complicated algorithmic interpretation of mutational pattern (sequence data). Since the sequencing procedure is not error free, it is often necessary to proceed into quality checking and manual editing of the raw data (chromatograms). This paper presents the design and development of a grid-based platform that assists the storage and analysis of HIV nucleotide sequences both for clinical practice and research purposes. Modular software components were implemented for sequence uploading, quality verification, mutation identification, genotypic resistance interpretation, phylogenetic analysis, multiple-sequence alignment and sophisticated mutation querying. Moreover these services have been exported as web services in order to provide a high layer of abstraction and enhanced collaboration among researchers. The platform has been validated and tested with more than 500 HIV sequences. © Springer-Verlag Berlin Heidelberg 2005. en
heal.publisher SPRINGER-VERLAG BERLIN en
heal.journalName Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) en
dc.identifier.doi 10.1007/11573036_44 en
dc.identifier.isi ISI:000233675500044 en
dc.identifier.volume 3746 LNCS en
dc.identifier.spage 469 en
dc.identifier.epage 479 en

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