Sensitivity investigations of surface stress capacitive DNA sensor

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dc.contributor.author Chatzandroulis, S en
dc.contributor.author Tsouti, V en
dc.contributor.author Gousrouridis, D en
dc.contributor.author Normand, P en
dc.contributor.author Boutopoulos, C en
dc.contributor.author Zergioti, I en
dc.contributor.author Tsoukalas, D en
dc.contributor.author Ioannou, M en
dc.contributor.author Kafetzopoulos, D en
dc.contributor.author Hue, J en
dc.contributor.author Rousier, R en
dc.date.accessioned 2014-03-01T02:46:59Z
dc.date.available 2014-03-01T02:46:59Z
dc.date.issued 2010 en
dc.identifier.uri http://hdl.handle.net/123456789/32971
dc.subject Surface Stress en
dc.subject.other Biological interactions en
dc.subject.other Biological targets en
dc.subject.other Biosensing elements en
dc.subject.other Biosensor arrays en
dc.subject.other Capacitive type en
dc.subject.other DNA sensors en
dc.subject.other matrix en
dc.subject.other Sample concentration en
dc.subject.other Sensing elements en
dc.subject.other Surface stress en
dc.subject.other Oligonucleotides en
dc.subject.other Polymerase chain reaction en
dc.subject.other Surface properties en
dc.subject.other Biosensors en
dc.title Sensitivity investigations of surface stress capacitive DNA sensor en
heal.type conferenceItem en
heal.identifier.primary 10.1109/ICSENS.2010.5690309 en
heal.identifier.secondary http://dx.doi.org/10.1109/ICSENS.2010.5690309 en
heal.identifier.secondary 5690309 en
heal.publicationDate 2010 en
heal.abstract Investigations of the sensitivity and selectivity of a capacitive type biosensor array, consisting of a total of 256 biosensing elements, in the detection of single oligonucleotide mutations is presented. The biosensor takes advantage of surface stress changes during biological interactions and is able to translate them into a capacitive signal. The array is organized in a 16x16 matrix of distinct biosensing elements thus allowing for the concurrent sensing of multiple biological targets. In this work the sensing elements of the array are spotted with three different oligonucleotides (CD8, CD17 and CD19) and their hybridization is detected using 36nM PCR. Moreover tests with CD19 revealed the ability of the biosensor to detect the hybridization of the oligo with sample concentrations of 36, 18 and 9nM. ©2010 IEEE. en
heal.journalName Proceedings of IEEE Sensors en
dc.identifier.doi 10.1109/ICSENS.2010.5690309 en
dc.identifier.spage 1554 en
dc.identifier.epage 1557 en

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