Local field potential driven Izhikevich model predicts a subthalamic nucleus neuron activity

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dc.contributor.author Michmizos, KP en
dc.contributor.author Nikita, KS en
dc.date.accessioned 2014-03-01T02:47:24Z
dc.date.available 2014-03-01T02:47:24Z
dc.date.issued 2011 en
dc.identifier.issn 1557170X en
dc.identifier.uri http://hdl.handle.net/123456789/33121
dc.subject.other Local field potentials en
dc.subject.other Microelectrode recording en
dc.subject.other Neuron activity en
dc.subject.other Parameterized en
dc.subject.other Parkinson's disease en
dc.subject.other Single neuron en
dc.subject.other Subthalamic nucleus en
dc.subject.other Electrophysiology en
dc.subject.other Microelectrodes en
dc.subject.other Professional aspects en
dc.subject.other Forecasting en
dc.title Local field potential driven Izhikevich model predicts a subthalamic nucleus neuron activity en
heal.type conferenceItem en
heal.identifier.primary 10.1109/IEMBS.2011.6091459 en
heal.identifier.secondary http://dx.doi.org/10.1109/IEMBS.2011.6091459 en
heal.identifier.secondary 6091459 en
heal.publicationDate 2011 en
heal.abstract An interesting question has been raised recently regarding the relationship between the local field potentials (LFPs) and the single unit spiking activity. In this study, we investigate whether a linear modification of the LFPs, acquired from microelectrode recordings inside the subthalamic nucleus (STN) of Parkinson's disease patients, can provide input to an appropriately parameterized Izhikevich model to predict the spikes of an STN neuron. We show that the model is able to predict both the exact timing and the rhythm of the recorded spikes with high accuracy in 5 out of 7 intranuclear single neuron recordings. For the rest of the models, one model shows a lower accuracy in predicting the rhythm and the second one shows a lower accuracy in predicting the timing of the spikes. Overall, the results dictate that the LFPs can reliably predict the occurrence of spikes. © 2011 IEEE. en
heal.journalName Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS en
dc.identifier.doi 10.1109/IEMBS.2011.6091459 en
dc.identifier.volume 2011 en
dc.identifier.spage 5900 en
dc.identifier.epage 5903 en

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