Evaluation of capacitive surface stress biosensors

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dc.contributor.author Tsouti, V en
dc.contributor.author Boutopoulos, C en
dc.contributor.author Ioannou, M en
dc.contributor.author Goustouridis, D en
dc.contributor.author Kafetzopoulos, D en
dc.contributor.author Zergioti, I en
dc.contributor.author Tsoukalas, D en
dc.contributor.author Normand, P en
dc.contributor.author Chatzandroulis, S en
dc.date.accessioned 2014-03-01T02:53:38Z
dc.date.available 2014-03-01T02:53:38Z
dc.date.issued 2012 en
dc.identifier.issn 01679317 en
dc.identifier.uri http://hdl.handle.net/123456789/36457
dc.subject Biosensor en
dc.subject Capacitive biosensor en
dc.subject DNA en
dc.subject Thin membrane en
dc.subject.other Biological interactions en
dc.subject.other Biological targets en
dc.subject.other Biosensing elements en
dc.subject.other Biosensor arrays en
dc.subject.other Capacitive biosensors en
dc.subject.other Capacitive type en
dc.subject.other matrix en
dc.subject.other Sample concentration en
dc.subject.other Sensing elements en
dc.subject.other Surface stress en
dc.subject.other Thin membrane en
dc.subject.other DNA en
dc.subject.other Oligonucleotides en
dc.subject.other Polymerase chain reaction en
dc.subject.other Surface properties en
dc.subject.other Biosensors en
dc.title Evaluation of capacitive surface stress biosensors en
heal.type conferenceItem en
heal.identifier.primary 10.1016/j.mee.2011.05.027 en
heal.identifier.secondary http://dx.doi.org/10.1016/j.mee.2011.05.027 en
heal.publicationDate 2012 en
heal.abstract The evaluation of a capacitive type biosensor array, consisting of a total of 256 biosensing elements, in the detection of single oligonucleotide mutations is presented. The biosensor takes advantage of surface stress changes during biological interactions and is able to translate them into a capacitive signal. The array is organized in a 16 × 16 matrix of distinct biosensing elements thus allowing for the concurrent sensing of multiple biological targets. In this work the sensing elements of the array are spotted with three different oligonucleotides (CD8, CD17 and CD19) and their hybridization is detected using 36 nM PCR. Moreover tests with CD19 revealed the ability of the biosensor to detect the hybridization of the oligo with sample concentrations of 36, 18 and 9 nM. © 2011 Elsevier B.V. All rights reserved. en
heal.journalName Microelectronic Engineering en
dc.identifier.doi 10.1016/j.mee.2011.05.027 en
dc.identifier.volume 90 en
dc.identifier.spage 37 en
dc.identifier.epage 39 en

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