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Mastocytosis with skin manifestations: current status

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dc.contributor.author Katsambas, AD en
dc.contributor.author Karpouzis, AJ en
dc.contributor.author Koumantaki-Mathioudaki, E en
dc.contributor.author Jorizzo, JL en
dc.date.accessioned 2014-03-01T11:45:43Z
dc.date.available 2014-03-01T11:45:43Z
dc.date.issued 1999 en
dc.identifier.issn 0926-9959 en
dc.identifier.uri http://hdl.handle.net/123456789/37583
dc.subject mastocytosis en
dc.subject mast cell en
dc.subject.classification Dermatology en
dc.subject.other MAST-CELL DISEASE en
dc.subject.other MACULARIS-ERUPTIVA-PERSTANS en
dc.subject.other BONE-MARROW FINDINGS en
dc.subject.other URTICARIA-PIGMENTOSA en
dc.subject.other SYSTEMIC MASTOCYTOSIS en
dc.subject.other CUTANEOUS MASTOCYTOSIS en
dc.subject.other ADHESION MOLECULES en
dc.subject.other TOPICAL STEROIDS en
dc.subject.other PROGENITOR CELLS en
dc.subject.other CATHEPSIN-G en
dc.title Mastocytosis with skin manifestations: current status en
heal.type other en
heal.language English en
heal.publicationDate 1999 en
heal.abstract Aim To review our present knowledge about mastocyte origin, mastocytosis classification and management. Methods Literature review. Results Mastocytoses are chronic and recurrent disorders with symptoms which might either be Limited only to the skin or to internal organs as well. The mastocytes, coming from bone marrow progenitor cells, migrate to tissues where they participate in inflammation and in cellular immunity as well as in the metabolism of connective and osseous tissues. Their proliferation causes the appearance of mastocytoses. The classification of the clinical manifestations of the mastocytoses into cutaneous, reactive (under the influence of the degranulator factors) and systemic disease, facilitates dialog among clinicians. Determination of prognosis and appropriate therapeutic regimens depend on individual features. Conclusions Mastocytosis diagnosis is verified by histological study of skin lesion biopsy material. Management is symptomatic and unfortunately does not eradicate the disease. (C) 1999 Elsevier Science B.V. All rights reserved. en
heal.publisher ELSEVIER SCIENCE BV en
heal.journalName JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY en
dc.identifier.isi ISI:000084840600001 en
dc.identifier.volume 13 en
dc.identifier.issue 3 en
dc.identifier.spage 155 en
dc.identifier.epage 165 en


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