Hydroxyapatite-biomolecule coatings onto titanium surfaces

Gonzalez-McQuire, R; Tsetsekou, A

dc.contributor.author	Gonzalez-McQuire, R	en
dc.contributor.author	Tsetsekou, A	en
dc.date.accessioned	2014-03-01T01:28:39Z
dc.date.available	2014-03-01T01:28:39Z
dc.date.issued	2008	en
dc.identifier.issn	0257-8972	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18893
dc.subject	Amino acids	en
dc.subject	Coating	en
dc.subject	Hydroxyapatite	en
dc.subject	Nanocomposites	en
dc.subject	Titanium	en
dc.subject.classification	Materials Science, Coatings & Films	en
dc.subject.classification	Physics, Applied	en
dc.subject.other	Bone implantation	en
dc.subject.other	Carboxyl end group	en
dc.subject.other	Coating adhesion	en
dc.subject.other	Covalent interactions	en
dc.subject.other	Functional coating	en
dc.subject.other	Gellation	en
dc.subject.other	HA coating	en
dc.subject.other	Implant surface	en
dc.subject.other	L-Arginine	en
dc.subject.other	l-Lysine	en
dc.subject.other	Load bearing	en
dc.subject.other	Metallic implants	en
dc.subject.other	Nano-structured	en
dc.subject.other	Nanoparticle formation	en
dc.subject.other	Osseointegration	en
dc.subject.other	Osteogenic cells	en
dc.subject.other	Powder XRD	en
dc.subject.other	SBF solution	en
dc.subject.other	SEM	en
dc.subject.other	Sol-gel routes	en
dc.subject.other	Surface structuring	en
dc.subject.other	TEM	en
dc.subject.other	Titanium implant surface	en
dc.subject.other	Titanium surfaces	en
dc.subject.other	Apatite	en
dc.subject.other	Biomaterials	en
dc.subject.other	Calcium carbide	en
dc.subject.other	Hydroxyapatite	en
dc.subject.other	Hydroxylation	en
dc.subject.other	Nanocomposites	en
dc.subject.other	Nanoparticles	en
dc.subject.other	Organic acids	en
dc.subject.other	Plasma spraying	en
dc.subject.other	Protective coatings	en
dc.subject.other	Sodium	en
dc.subject.other	Sol-gel process	en
dc.subject.other	Titanium	en
dc.subject.other	Amino acids	en
dc.title	Hydroxyapatite-biomolecule coatings onto titanium surfaces	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.surfcoat.2008.07.034	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.surfcoat.2008.07.034	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	To date, surface structuring of metallic implants for use in load bearing bone implantation focuses on the coating of their surface with hydroxyapatite (HA) through plasma spraying. Despite the inherent disadvantages of this method, research on alternative coating techniques has been slow to yield suitable results, mostly due to the lack of surface tailoring for efficient osseointegration coupled with inefficient coating adhesion to the implant surface. Through the presented work we provide a new route for the formation of nanostructured functional coatings of HA onto titanium implant surfaces employing amino acids to not only potentially induce osteogenic cell activity, but to aid the attachment of HA onto the titanium surface. Briefly, crystalline, partially carbonated HA nanoparticles were synthesised through a novel sol-gel route employing CaCl2 and Na2HPO4 as precursors and L-arginine or L-lysine to facilitate nanoparticle formation and gellation and to control the viscosity of the slurries. The grafted amino acids were in turn used to attach the HA coating through covalent interactions between the amino acid carboxyl end groups and the TiOH groups on the titanium surface. The composites were characterised by SEM, TEM, powder XRD, FF-IR, scratch and roughness testing. Samples were also treated in an SBF solution to observe their bioactivity. (C) 2008 Elsevier B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE SA	en
heal.journalName	Surface and Coatings Technology	en
dc.identifier.doi	10.1016/j.surfcoat.2008.07.034	en
dc.identifier.isi	ISI:000260884500027	en
dc.identifier.volume	203	en
dc.identifier.issue	1-2	en
dc.identifier.spage	186	en
dc.identifier.epage	190	en