Thermal distribution in biological tissue at laser induced fluorescence and photodynamic therapy

Krasnikov, IV; Seteikin, AYu; Drakaki, E; Makropoulou, M

dc.contributor.author	Krasnikov, IV	en
dc.contributor.author	Seteikin, AYu	en
dc.contributor.author	Drakaki, E	en
dc.contributor.author	Makropoulou, M	en
dc.date.accessioned	2014-03-01T02:54:02Z
dc.date.available	2014-03-01T02:54:02Z
dc.date.issued	2012	en
dc.identifier.issn	16057422	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/36557
dc.subject	Heat transfer	en
dc.subject	Laser influence	en
dc.subject	Monte Carlo simulation	en
dc.subject	Skin	en
dc.subject	Temperature distribution	en
dc.subject.other	Biological tissues	en
dc.subject.other	Clinical application	en
dc.subject.other	Continuous Wave	en
dc.subject.other	Laser induced fluorescence	en
dc.subject.other	Laser induced fluorescence spectroscopy	en
dc.subject.other	Monte Carlo modeling	en
dc.subject.other	Monte Carlo Simulation	en
dc.subject.other	Optical energy	en
dc.subject.other	Power densities	en
dc.subject.other	Pulsed UV-lasers	en
dc.subject.other	Simultaneous formation	en
dc.subject.other	Skin tissue	en
dc.subject.other	Surface illumination	en
dc.subject.other	Thermal distributions	en
dc.subject.other	Tissue temperatures	en
dc.subject.other	Visible lasers	en
dc.subject.other	Coagulation	en
dc.subject.other	Fluorescence spectroscopy	en
dc.subject.other	Heat transfer	en
dc.subject.other	Laser optics	en
dc.subject.other	Monte Carlo methods	en
dc.subject.other	Optical instruments	en
dc.subject.other	Photodynamic therapy	en
dc.subject.other	Skin	en
dc.subject.other	Temperature distribution	en
dc.subject.other	Visualization	en
dc.subject.other	Tissue	en
dc.title	Thermal distribution in biological tissue at laser induced fluorescence and photodynamic therapy	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1117/12.923741	en
heal.identifier.secondary	http://dx.doi.org/10.1117/12.923741	en
heal.identifier.secondary	83370E	en
heal.publicationDate	2012	en
heal.abstract	Laser induced fluorescence spectroscopy and photodynamic therapy (PDT) are techniques currently introduced in clinical applications for visualization and local destruction of malignant tumours as well as premalignant lesions. During the laser irradiation of tissues for the diagnostic and therapeutic purposes, the absorbed optical energy generates heat, although the power density of the treatment light for surface illumination is normally low enough not to cause any significantly increased tissue temperature. In this work we tried to evaluate the utility of Monte Carlo modeling for simulating the temperature fields and the dynamics of heat conduction into the skin tissue under several laser irradiation conditions with both a pulsed UV laser and a continuous wave visible laser beam. The analysis of the results showed that heat is not localized on the surface, but it is collected inside the tissue. By varying the boundary conditions on the surface and the type of the laser radiation (continuous or pulsed) we can reach higher than normal temperature inside the tissue without simultaneous formation of thermally damaged tissue (e.g. coagulation or necrosis zone). © 2012 SPIE.	en
heal.journalName	Progress in Biomedical Optics and Imaging - Proceedings of SPIE	en
dc.identifier.doi	10.1117/12.923741	en
dc.identifier.volume	8337	en