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Radiation chemistry of cis-platinum-nucleotide complexes

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dc.contributor.author Anastassopoulou, JD en
dc.contributor.author Brekoulakis, JS en
dc.date.accessioned 2014-03-01T01:08:07Z
dc.date.available 2014-03-01T01:08:07Z
dc.date.issued 1990 en
dc.identifier.issn 0250-7005 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/10285
dc.relation.uri http://www.scopus.com/inward/record.url?eid=2-s2.0-0025314598&partnerID=40&md5=18647f950520b0616e3087067f814a4e en
dc.subject Cis-platinum en
dc.subject nucleotide complexes en
dc.subject radiation chemistry en
dc.subject radiosensitizers en
dc.subject.classification Oncology en
dc.subject.other cisplatin en
dc.subject.other guanosine phosphate en
dc.subject.other article en
dc.subject.other human en
dc.subject.other nonhuman en
dc.subject.other priority journal en
dc.subject.other radiochemistry en
dc.subject.other radiolysis en
dc.subject.other 5'-Guanylic Acid en
dc.subject.other Chromatography, High Pressure Liquid en
dc.subject.other Cisplatin en
dc.subject.other Radiochemistry en
dc.title Radiation chemistry of cis-platinum-nucleotide complexes en
heal.type journalArticle en
heal.language English en
heal.publicationDate 1990 en
heal.abstract The mechanism of γ-radiolysis of cis-dichlorodiamineplatinum (II) (cis-Platinum) with guanosine-5'-monophosphate (L) complexes in aqueous solutions was investigated. The decomposition limiting yield G (-cis-Pt (NH3)2L2) in deaerated and nitrous oxide saturated solutions, determined by measuring the absorbance at 254 nm, was found to be 0.8 and 1.2, respectively. It was found from HPLC that, upon irradiation of the complexes, guanosine-5'-monophosphate, guanosine and guanine were released. Other products, such as sugarphosphate and sugar, could not be detected with this UV-method. en
heal.publisher INT INST ANTICANCER RESEARCH en
heal.journalName Anticancer Research en
dc.identifier.isi ISI:A1990DT86900023 en
dc.identifier.volume 10 en
dc.identifier.issue 4 en
dc.identifier.spage 983 en
dc.identifier.epage 986 en


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