Radiation chemistry of cis-platinum-nucleotide complexes

Anastassopoulou, JD; Brekoulakis, JS

dc.contributor.author	Anastassopoulou, JD	en
dc.contributor.author	Brekoulakis, JS	en
dc.date.accessioned	2014-03-01T01:08:07Z
dc.date.available	2014-03-01T01:08:07Z
dc.date.issued	1990	en
dc.identifier.issn	0250-7005	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/10285
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0025314598&partnerID=40&md5=18647f950520b0616e3087067f814a4e	en
dc.subject	Cis-platinum	en
dc.subject	nucleotide complexes	en
dc.subject	radiation chemistry	en
dc.subject	radiosensitizers	en
dc.subject.classification	Oncology	en
dc.subject.other	cisplatin	en
dc.subject.other	guanosine phosphate	en
dc.subject.other	article	en
dc.subject.other	human	en
dc.subject.other	nonhuman	en
dc.subject.other	priority journal	en
dc.subject.other	radiochemistry	en
dc.subject.other	radiolysis	en
dc.subject.other	5'-Guanylic Acid	en
dc.subject.other	Chromatography, High Pressure Liquid	en
dc.subject.other	Cisplatin	en
dc.subject.other	Radiochemistry	en
dc.title	Radiation chemistry of cis-platinum-nucleotide complexes	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1990	en
heal.abstract	The mechanism of γ-radiolysis of cis-dichlorodiamineplatinum (II) (cis-Platinum) with guanosine-5'-monophosphate (L) complexes in aqueous solutions was investigated. The decomposition limiting yield G (-cis-Pt (NH3)2L2) in deaerated and nitrous oxide saturated solutions, determined by measuring the absorbance at 254 nm, was found to be 0.8 and 1.2, respectively. It was found from HPLC that, upon irradiation of the complexes, guanosine-5'-monophosphate, guanosine and guanine were released. Other products, such as sugarphosphate and sugar, could not be detected with this UV-method.	en
heal.publisher	INT INST ANTICANCER RESEARCH	en
heal.journalName	Anticancer Research	en
dc.identifier.isi	ISI:A1990DT86900023	en
dc.identifier.volume	10	en
dc.identifier.issue	4	en
dc.identifier.spage	983	en
dc.identifier.epage	986	en