Optimal steady-state temperature distribution for a phased array hyperthermia system

Nikita, KS; Maratos, NG; Uzunoglu, NK

dc.contributor.author	Nikita, KS	en
dc.contributor.author	Maratos, NG	en
dc.contributor.author	Uzunoglu, NK	en
dc.date.accessioned	2014-03-01T01:09:29Z
dc.date.available	2014-03-01T01:09:29Z
dc.date.issued	1993	en
dc.identifier.issn	0018-9294	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/11025
dc.subject	Phased Array	en
dc.subject	Steady State	en
dc.subject	Temperature Distribution	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.other	Arrays	en
dc.subject.other	Electric heating elements	en
dc.subject.other	Heat transfer	en
dc.subject.other	Mathematical models	en
dc.subject.other	Hyperthermia systems	en
dc.subject.other	Phased arrays	en
dc.subject.other	Hyperthermia therapy	en
dc.subject.other	algorithm	en
dc.subject.other	article	en
dc.subject.other	controlled study	en
dc.subject.other	electromagnetic field	en
dc.subject.other	hyperthermic therapy	en
dc.subject.other	steady state	en
dc.subject.other	temperature sensitivity	en
dc.subject.other	tumor volume	en
dc.subject.other	Electromagnetics	en
dc.subject.other	Equipment Design	en
dc.subject.other	Human	en
dc.subject.other	Hyperthermia, Induced	en
dc.subject.other	Mathematics	en
dc.subject.other	Models, Biological	en
dc.subject.other	Neoplasms	en
dc.subject.other	Temperature	en
dc.title	Optimal steady-state temperature distribution for a phased array hyperthermia system	en
heal.type	journalArticle	en
heal.identifier.primary	10.1109/10.250585	en
heal.identifier.secondary	http://dx.doi.org/10.1109/10.250585	en
heal.language	English	en
heal.publicationDate	1993	en
heal.abstract	A method is presented for the evaluation of optimal amplitude and phase excitations for the radiating elements of a phased array hyperthermia system, in order to achieve desired steady-state temperature distributions inside and outside of malignant tissues. Use is made of a detailed electromagnetic and thermal model of the heated tissue in order to predict the steady-state temperature at any point in tissue. Optimal excitations are obtained by minimizing the squared error between desired and model predicted temperatures inside the tumor volume, subject to the constraint that temperatures do not exceed an upper bound outside the tumor. The penalty function technique is used to solve the constrained optimization problem. Sequential unconstrained minima are obtained by a modified Newton method. Numerical results for a four element phased array hyperthermia system are presented.A method is presented for the evaluation of optimal amplitude and phase excitations for the radiating elements of a phased array hyperthermia system, in order to achieve desired steady-state temperature distributions inside and outside of malignant tissues. Use is made of a detailed electromagnetic and thermal model of the heated tissue in order to predict the steady-state temperature at any point in tissue. Optimal excitations are obtained by minimizing the squared error between desired and model predicted temperatures inside the tumor volume, subject to the constraint that temperatures do not exceed an upper bound outside the tumor. The penalty function technique is used to solve the constrained optimization problem. Sequential unconstrained minima are obtained by a modified Newton method. Numerical results for a four element phased array hyperthermia system are presented.	en
heal.publisher	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC	en
heal.journalName	IEEE Transactions on Biomedical Engineering	en
dc.identifier.doi	10.1109/10.250585	en
dc.identifier.isi	ISI:A1993MP94900012	en
dc.identifier.volume	40	en
dc.identifier.issue	12	en
dc.identifier.spage	1299	en
dc.identifier.epage	1306	en