Comparative evaluation of combined irradiation and hyperthermia versus irradiation alone

Sawas-Dimopoulou, C; Papavasilion, C; Iordanou, I; Uzunoglu, N; Dardoufas, K; Kouloulias, V; Maris, T; Kotaridis, S

dc.contributor.author	Sawas-Dimopoulou, C	en
dc.contributor.author	Papavasilion, C	en
dc.contributor.author	Iordanou, I	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Dardoufas, K	en
dc.contributor.author	Kouloulias, V	en
dc.contributor.author	Maris, T	en
dc.contributor.author	Kotaridis, S	en
dc.date.accessioned	2014-03-01T01:09:46Z
dc.date.available	2014-03-01T01:09:46Z
dc.date.issued	1994	en
dc.identifier.issn	09387994	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/11183
dc.subject	Experimental tumour	en
dc.subject	Solid tumour	en
dc.subject	Tumour-bearing rats	en
dc.subject	Walker carcinoma	en
dc.subject	X-ray treatment combined with hyperthermia	en
dc.title	Comparative evaluation of combined irradiation and hyperthermia versus irradiation alone	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/BF00231204	en
heal.identifier.secondary	http://dx.doi.org/10.1007/BF00231204	en
heal.publicationDate	1994	en
heal.abstract	Controvesy remains as to the treatment schedule producing better results in combined hyperthermia and X-ray therapy. Our experience concerning combined therapy of the solid tumour Walker carcinoma is reported. Male Wistar rats were submitted to treatment on the ninth day after transplantation of the tumour. Two groups of rats received either a therapeutic X-ray dose of 800 cGy by a 6-MeV linear accelerator (Mevatron, Siemens) or treatment by 432 MHz of microwaves with continuous control of tumour tissue temperature to 44 ± 1 °C for 45 min. Another group of rats was submitted to a combined treatment, with X-ray therapy preceding hyperthermia by 24 h. The last group of animals constituted the control rats. Greater tumour regression and longer survival times were obtained with the combined treatment. The gain factor for survival time was equal to 1.85 after combined treatment compared with 1.30 after X-ray therapy and 1.05 after hyperthermia. In conclusion, the results suggest that in the above schedule of combined treatment, hyperthermia applied to a solid tumour 24 h after a single dose of X-rays enhances the beneficial effect of therapy. © 1994 Springer-Verlag.	en
heal.publisher	Springer-Verlag	en
heal.journalName	European Radiology	en
dc.identifier.doi	10.1007/BF00231204	en
dc.identifier.volume	4	en
dc.identifier.issue	2	en
dc.identifier.spage	167	en
dc.identifier.epage	171	en