In vitro release of new quinolones from biodegradable systems: A comparative study

Andreopoulos, AG; Korakis, T; Dounis, E; Anastasiadis, A; Tzivelekis, P; Kanellakopoulou, K

dc.contributor.author	Andreopoulos, AG	en
dc.contributor.author	Korakis, T	en
dc.contributor.author	Dounis, E	en
dc.contributor.author	Anastasiadis, A	en
dc.contributor.author	Tzivelekis, P	en
dc.contributor.author	Kanellakopoulou, K	en
dc.date.accessioned	2014-03-01T01:11:59Z
dc.date.available	2014-03-01T01:11:59Z
dc.date.issued	1996	en
dc.identifier.issn	0885-3282	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/11912
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0030111847&partnerID=40&md5=314ebefc9fc7a87c3ad6e406f66c3bd9	en
dc.subject	Biodegradable polymers	en
dc.subject	Ciprofioxacin	en
dc.subject	Drug delivery systems	en
dc.subject	New quinolones	en
dc.subject	Ofloxacin	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	Antibiotics	en
dc.subject.other	Bacteria	en
dc.subject.other	Biodegradation	en
dc.subject.other	Bone	en
dc.subject.other	Diseases	en
dc.subject.other	Molecular weight	en
dc.subject.other	Organic compounds	en
dc.subject.other	Organic polymers	en
dc.subject.other	Ciprofloxacin	en
dc.subject.other	Minimum inhibitory concentration	en
dc.subject.other	Ofloxacin	en
dc.subject.other	Osteomyelitis	en
dc.subject.other	Polylactic acid	en
dc.subject.other	Quinolones	en
dc.subject.other	Controlled drug delivery	en
dc.subject.other	antiinfective agent	en
dc.subject.other	ciprofloxacin	en
dc.subject.other	drug carrier	en
dc.subject.other	lactic acid	en
dc.subject.other	ofloxacin	en
dc.subject.other	polylactic acid	en
dc.subject.other	polymer	en
dc.subject.other	article	en
dc.subject.other	bioremediation	en
dc.subject.other	chemistry	en
dc.subject.other	comparative study	en
dc.subject.other	culture medium	en
dc.subject.other	delayed release formulation	en
dc.subject.other	diffusion	en
dc.subject.other	drug delivery system	en
dc.subject.other	in vitro study	en
dc.subject.other	molecular weight	en
dc.subject.other	statistics	en
dc.subject.other	time	en
dc.subject.other	Anti-Infective Agents	en
dc.subject.other	Biodegradation, Environmental	en
dc.subject.other	Ciprofloxacin	en
dc.subject.other	Culture Media	en
dc.subject.other	Delayed-Action Preparations	en
dc.subject.other	Diffusion	en
dc.subject.other	Drug Carriers	en
dc.subject.other	Drug Delivery Systems	en
dc.subject.other	Lactic Acid	en
dc.subject.other	Molecular Weight	en
dc.subject.other	Ofloxacin	en
dc.subject.other	Polymers	en
dc.subject.other	Time Factors	en
dc.title	In vitro release of new quinolones from biodegradable systems: A comparative study	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1996	en
heal.abstract	A new biodegradable delivery system based on low molecular weight poly(lactic acid) has been formualted, with potential application in the sustained antibiotic release against bone infection. The in vitro release of two new quinolones (ofloxacin and ciproftoxacin) from the biodegradable matrix showed that the delivery of ofloxacin from the matrix lasted fifty-six days, whereas that of ciprofloxacin lasted fifty-one days. In both cases, release is controlled by the drug diffusion and the matrix degradation, the latter being the most critical factor. The obtained concentration levels are well above the Minimum Inhibitory Concentration (MIC) against the major causative bacteria of osteomyelitis. This fact in combination with the good reproducibility of measurements indicated that the system studied could be of value for the preparation of implantable controlled release systems for treatment of diseases in the bone system.	en
heal.publisher	TECHNOMIC PUBL CO INC	en
heal.journalName	Journal of Biomaterials Applications	en
dc.identifier.isi	ISI:A1996UH63800003	en
dc.identifier.volume	10	en
dc.identifier.issue	4	en
dc.identifier.spage	338	en
dc.identifier.epage	347	en