Reactions of 2-methyl-3,1-benzoxazin-4-one with active methylene compounds: A new route to 3-substituted 4-hydroxyquinolin-2(1H)-ones

Detsi, A; Bardakos, V; Markopoulos, J; Igglessi-Markopoulou, O

dc.contributor.author	Detsi, A	en
dc.contributor.author	Bardakos, V	en
dc.contributor.author	Markopoulos, J	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:12:13Z
dc.date.available	2014-03-01T01:12:13Z
dc.date.issued	1996	en
dc.identifier.issn	0300-922X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/12016
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	SUBSTITUTED TETRAMIC ACIDS	en
dc.subject.other	GLYCINE-SITE	en
dc.subject.other	ACYLAMINOACETYL DERIVATIVES	en
dc.subject.other	RECEPTOR ANTAGONISTS	en
dc.subject.other	QUINOLINE ALKALOIDS	en
dc.subject.other	ISATOIC ANHYDRIDE	en
dc.subject.other	4-HYDROXY-2-QUINOLONES	en
dc.subject.other	2-QUINOLONE	en
dc.subject.other	CYCLIZATION	en
dc.subject.other	CHEMISTRY	en
dc.title	Reactions of 2-methyl-3,1-benzoxazin-4-one with active methylene compounds: A new route to 3-substituted 4-hydroxyquinolin-2(1H)-ones	en
heal.type	journalArticle	en
heal.identifier.primary	10.1039/p19960002909	en
heal.identifier.secondary	http://dx.doi.org/10.1039/p19960002909	en
heal.language	English	en
heal.publicationDate	1996	en
heal.abstract	A new route to 3-substituted 4-hydroxyquinolin-2(1H)-ones, compounds of great biological importance, is described. The C-acylation of active methylene compounds 2 with the 2-methyl-3,1-benzoxazin-4-one 1, under basic conditions, leads to the formation of the new products 3-10, which have been isolated and characterized. Cyclization of the above intermediates furnishes the 3-substituted 4-hydroxyquinolin-2(1H)-ones. Spectral data and physical characteristics for all compounds are reported.	en
heal.publisher	ROYAL SOC CHEMISTRY	en
heal.journalName	Journal of the Chemical Society - Perkin Transactions 1	en
dc.identifier.doi	10.1039/p19960002909	en
dc.identifier.isi	ISI:A1996WB36600009	en
dc.identifier.issue	24	en
dc.identifier.spage	2909	en
dc.identifier.epage	2913	en