Reactions of 2-methyl-4H-pyrido[2,3-d][3,1]oxazin-4-one with active methylene compounds: A new efficient route to 3-substituted 4-hydroxy-1,8-naphthyridin-2(1H)-ones

Delieza, V; Detsi, A; Bardakos, V; Igglessi-Markopoulou, O

dc.contributor.author	Delieza, V	en
dc.contributor.author	Detsi, A	en
dc.contributor.author	Bardakos, V	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:13:18Z
dc.date.available	2014-03-01T01:13:18Z
dc.date.issued	1997	en
dc.identifier.issn	0300-922X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/12412
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	ACID-DERIVATIVES	en
dc.subject.other	INHIBITOR	en
dc.subject.other	SCH-37224	en
dc.subject.other	LS-2616	en
dc.title	Reactions of 2-methyl-4H-pyrido[2,3-d][3,1]oxazin-4-one with active methylene compounds: A new efficient route to 3-substituted 4-hydroxy-1,8-naphthyridin-2(1H)-ones	en
heal.type	journalArticle	en
heal.identifier.primary	10.1039/a608509a	en
heal.identifier.secondary	http://dx.doi.org/10.1039/a608509a	en
heal.language	English	en
heal.publicationDate	1997	en
heal.abstract	3-Substituted 1,8-naphthyridine-2,4-diones, compounds of very important pharmaceutical use, have been synthesized using a new efficient route. The reaction of 2-methyl-4H-pyrido-[2,3-d][3,1]oxazin-4-one, 1b, with active methylene compounds furnishes the 1-acetyl-3-substituted-4-hydroxy-1,8-naphthyridin-2-ones 3-5, in good yields. In the case of cyanoacetic esters the intermediate C-acylation compounds 7 and 8 were isolated and subsequently cyclized to 1-acetyl-3-cyano-4-hydroxy-1,8-naphthyridin-2-one 6. Spectral data and physical characteristics for all compounds are reported.	en
heal.publisher	ROYAL SOC CHEMISTRY	en
heal.journalName	Journal of the Chemical Society - Perkin Transactions 1	en
dc.identifier.doi	10.1039/a608509a	en
dc.identifier.isi	ISI:A1997XC27900007	en
dc.identifier.issue	10	en
dc.identifier.spage	1487	en
dc.identifier.epage	1490	en