Application of the Monte Carlo integration (MCI) method for calculation of the anisotropy of 192Ir brachytherapy sources

Baltas, D; Giannouli, S; Garbi, A; Diakonos, F; Geramani, K; Ioannidis, GT; Tsalpatouros, A; Uzunoglu, N; Kolotas, C; Zamboglou, N

dc.contributor.author	Baltas, D	en
dc.contributor.author	Giannouli, S	en
dc.contributor.author	Garbi, A	en
dc.contributor.author	Diakonos, F	en
dc.contributor.author	Geramani, K	en
dc.contributor.author	Ioannidis, GT	en
dc.contributor.author	Tsalpatouros, A	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Kolotas, C	en
dc.contributor.author	Zamboglou, N	en
dc.date.accessioned	2014-03-01T01:13:35Z
dc.date.available	2014-03-01T01:13:35Z
dc.date.issued	1998	en
dc.identifier.issn	0031-9155	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/12591
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	iridium 192	en
dc.subject.other	anisotropy	en
dc.subject.other	article	en
dc.subject.other	dosimetry	en
dc.subject.other	mathematical analysis	en
dc.subject.other	priority journal	en
dc.subject.other	radiation dose	en
dc.subject.other	radioisotope therapy	en
dc.subject.other	system analysis	en
dc.subject.other	Algorithms	en
dc.subject.other	Anisotropy	en
dc.subject.other	Biophysics	en
dc.subject.other	Brachytherapy	en
dc.subject.other	Humans	en
dc.subject.other	Iridium Radioisotopes	en
dc.subject.other	Models, Theoretical	en
dc.subject.other	Monte Carlo Method	en
dc.subject.other	Neoplasms	en
dc.subject.other	Quality Control	en
dc.subject.other	Radiotherapy Dosage	en
dc.subject.other	Radiotherapy Planning, Computer-Assisted	en
dc.subject.other	Technology, Radiologic	en
dc.title	Application of the Monte Carlo integration (MCI) method for calculation of the anisotropy of 192Ir brachytherapy sources	en
heal.type	journalArticle	en
heal.identifier.primary	10.1088/0031-9155/43/6/029	en
heal.identifier.secondary	http://dx.doi.org/10.1088/0031-9155/43/6/029	en
heal.language	English	en
heal.publicationDate	1998	en
heal.abstract	Source anisotropy is a very important factor in the brachytherapy quality assurance of high-dose rate (HDR) Ir-192 afterloading stepping sources. If anisotropy is not taken into account then doses received by a brachytherapy patient in certain directions can be in error by a clinically significant amount. Experimental measurements of anisotropy are very labour intensive. We have shown that within acceptable limits of accuracy, Monte Carlo integration (MCI) of a modified Sievert integral (3D generalization) can provide the necessary data within a much shorter time scale than can experiments. Hence MCI can be used for routine quality assurance schedules whenever a new design of HDR or PDR Ir-192 is used for brachytherapy afterloading. Our MCI calculation results are compared with published experimental data and Monte Carlo simulation data for microSelectron and VariSource Ir-192 sources. We have shown not only that MCI offers advantages over alternative numerical integration methods, but also that treating filtration coefficients as radial distance-dependent functions improves Sievert integral accuracy at low energies. This paper also provides anisotropy data for three new Ir-192 sources, one for the microSelectron-HDR and two for the microSelectron-PDR, for which data are currently not available. The information we have obtained in this study can be incorporated into clinical practice.	en
heal.publisher	IOP PUBLISHING LTD	en
heal.journalName	Physics in Medicine and Biology	en
dc.identifier.doi	10.1088/0031-9155/43/6/029	en
dc.identifier.isi	ISI:000074257600029	en
dc.identifier.volume	43	en
dc.identifier.issue	6	en
dc.identifier.spage	1783	en
dc.identifier.epage	1801	en