Azocrosslinked poly(acrylic acid) for colonic delivery and adhesion specificity: In vitro degradation and preliminary ex vivo bioadhesion studies

Kakoulides, EP; Smart, JD; Tsibouklis, J

dc.contributor.author	Kakoulides, EP	en
dc.contributor.author	Smart, JD	en
dc.contributor.author	Tsibouklis, J	en
dc.date.accessioned	2014-03-01T01:13:36Z
dc.date.available	2014-03-01T01:13:36Z
dc.date.issued	1998	en
dc.identifier.issn	0168-3659	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/12602
dc.subject	Azopolymers	en
dc.subject	Azoreduction	en
dc.subject	Biodegradable hydrogels	en
dc.subject	Colon-specific drug delivery	en
dc.subject	Mucoadhesion	en
dc.subject.classification	Chemistry, Multidisciplinary	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.other	4,4' divinylazobenzene	en
dc.subject.other	azo compound	en
dc.subject.other	benzylviologen	en
dc.subject.other	carbomer	en
dc.subject.other	glucose 6 phosphate	en
dc.subject.other	glucose 6 phosphate dehydrogenase	en
dc.subject.other	nicotinamide adenine dinucleotide phosphate	en
dc.subject.other	polyacrylic acid	en
dc.subject.other	tartrazine	en
dc.subject.other	unclassified drug	en
dc.subject.other	adhesion	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	atomic force microscopy	en
dc.subject.other	biodegradation	en
dc.subject.other	cell free system	en
dc.subject.other	colon mucosa	en
dc.subject.other	controlled study	en
dc.subject.other	cross linking	en
dc.subject.other	drug delivery system	en
dc.subject.other	hydrogel	en
dc.subject.other	infrared spectroscopy	en
dc.subject.other	male	en
dc.subject.other	nonhuman	en
dc.subject.other	priority journal	en
dc.subject.other	rat	en
dc.subject.other	scanning electron microscopy	en
dc.subject.other	surface property	en
dc.subject.other	Acrylic Resins	en
dc.subject.other	Animals	en
dc.subject.other	Azo Compounds	en
dc.subject.other	Cell Adhesion	en
dc.subject.other	Cell-Free System	en
dc.subject.other	Colon	en
dc.subject.other	Cross-Linking Reagents	en
dc.subject.other	Drug Carriers	en
dc.subject.other	Intestinal Mucosa	en
dc.subject.other	Male	en
dc.subject.other	Microscopy, Atomic Force	en
dc.subject.other	Rats	en
dc.subject.other	Rats, Wistar	en
dc.title	Azocrosslinked poly(acrylic acid) for colonic delivery and adhesion specificity: In vitro degradation and preliminary ex vivo bioadhesion studies	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/S0168-3659(98)00004-2	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S0168-3659(98)00004-2	en
heal.language	English	en
heal.publicationDate	1998	en
heal.abstract	This study reports on the performance of a novel polymeric material that is capable of providing site specificity in active agent delivery and the development of mucoadhesive interactions. Ate-networks, based on an acrylic backbone crosslinked with 4,4'-divinylazobenzene, were subjected to in vitro degradation and mucoadhesion (before and after degradation) testing in order to model their performance in the gastrointestinal tract. Advanced surface characterisation techniques (SEM, AFM, FTIR microscopy) were used to examine the network morphology prior to, and after degradation. The data obtained from these studies indicate that there is an optimum crosslinking density to allow non-adhesive particles to reach the colon. Within the colonic environment, the ate network degrades to produce a structure capable of developing mucoadhesive interactions with the colonic mucosa. (C) 1998 Elsevier Science B.V.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Journal of Controlled Release	en
dc.identifier.doi	10.1016/S0168-3659(98)00004-2	en
dc.identifier.isi	ISI:000074043000010	en
dc.identifier.volume	54	en
dc.identifier.issue	1	en
dc.identifier.spage	95	en
dc.identifier.epage	109	en