Biomedical silicone elastomers as carriers for controlled release

Andreopoulos, AG; Plytaria, M

dc.contributor.author	Andreopoulos, AG	en
dc.contributor.author	Plytaria, M	en
dc.date.accessioned	2014-03-01T01:13:37Z
dc.date.available	2014-03-01T01:13:37Z
dc.date.issued	1998	en
dc.identifier.issn	0885-3282	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/12608
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0031594446&partnerID=40&md5=c53b1e69101ff36b51b3a172909092bf	en
dc.subject	Biomedical elastomers	en
dc.subject	Controlled release of drugs	en
dc.subject	Membranes	en
dc.subject	Propranolol	en
dc.subject	Silicones	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	Carboxylic acids	en
dc.subject.other	Chlorine compounds	en
dc.subject.other	Controlled drug delivery	en
dc.subject.other	Crosslinking	en
dc.subject.other	Elastomers	en
dc.subject.other	Gels	en
dc.subject.other	Silicones	en
dc.subject.other	Swelling	en
dc.subject.other	Toluene	en
dc.subject.other	Propranolol hydrochloride	en
dc.subject.other	Salicylic acid	en
dc.subject.other	Biomaterials	en
dc.subject.other	biomaterial	en
dc.subject.other	propranolol	en
dc.subject.other	salicylic acid	en
dc.subject.other	salicylic acid derivative	en
dc.subject.other	silastic	en
dc.subject.other	article	en
dc.subject.other	drug delivery system	en
dc.subject.other	Biocompatible Materials	en
dc.subject.other	Drug Delivery Systems	en
dc.subject.other	Propranolol	en
dc.subject.other	Salicylic Acid	en
dc.subject.other	Salicylic Acids	en
dc.subject.other	Silicone Elastomers	en
dc.title	Biomedical silicone elastomers as carriers for controlled release	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1998	en
heal.abstract	Biomedical silicone elastomers have been studied for their potential application as carriers for controlled release of drugs, since these materials display a unique combination of properties, which might be favorable to the above use. A two component silicone gel system was used and various cross-linker ratio was applied, in order to produce networks with varying crosslink density. Swelling experiments in toluene were run in order to evaluate the network characteristics. The silicone elastomer was loaded with salicylic acid and propranolol hydrochloride and their delivery in distilled water was followed. The results showed that release is almost of zero order for high loading of salicylic acid, while delivery seems to be diffusion controlled up to a certain limit. The administered drug concentrations are relatively low if silicone discs are used, due to the hydrophobic nature of this material. On the other hand, when membranes are used with a thickness of 0.1-0.2 mm, then the delivery rate is much higher depending of course on the hydrophilic character of the drug.	en
heal.publisher	TECHNOMIC PUBL CO INC	en
heal.journalName	Journal of Biomaterials Applications	en
dc.identifier.isi	ISI:000071887400005	en
dc.identifier.volume	12	en
dc.identifier.issue	3	en
dc.identifier.spage	258	en
dc.identifier.epage	271	en