Short column gas chromatography-mass spectrometry and principal component analysis for the identification of coeluted substances in doping control analysis

Statheropoulos, M; Tzamtzis, N; Mikedi, K

dc.contributor.author	Statheropoulos, M	en
dc.contributor.author	Tzamtzis, N	en
dc.contributor.author	Mikedi, K	en
dc.date.accessioned	2014-03-01T01:14:09Z
dc.date.available	2014-03-01T01:14:09Z
dc.date.issued	1998	en
dc.identifier.issn	0378-4347	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/12890
dc.subject	Cocaine	en
dc.subject	Dextromethorphan	en
dc.subject	Dextropropoxyphene	en
dc.subject	Doping control	en
dc.subject	Methadone	en
dc.subject	Principal component analysis	en
dc.subject.classification	Biochemical Research Methods	en
dc.subject.classification	Chemistry, Analytical	en
dc.subject.other	cocaine	en
dc.subject.other	dextromethorphan	en
dc.subject.other	dextropropoxyphene	en
dc.subject.other	methadone	en
dc.subject.other	article	en
dc.subject.other	doping	en
dc.subject.other	drug determination	en
dc.subject.other	drug mixture	en
dc.subject.other	gas chromatography	en
dc.subject.other	human	en
dc.subject.other	mass spectrometry	en
dc.subject.other	mathematics	en
dc.subject.other	principal component analysis	en
dc.subject.other	priority journal	en
dc.subject.other	quantitative assay	en
dc.subject.other	spectrometry	en
dc.subject.other	technique	en
dc.subject.other	theory	en
dc.subject.other	Cocaine	en
dc.subject.other	Dextromethorphan	en
dc.subject.other	Factor Analysis, Statistical	en
dc.subject.other	Gas Chromatography-Mass Spectrometry	en
dc.subject.other	Methadone	en
dc.subject.other	Narcotics	en
dc.subject.other	Propoxyphene	en
dc.subject.other	Software	en
dc.subject.other	Substance Abuse Detection	en
dc.subject.other	Time Factors	en
dc.title	Short column gas chromatography-mass spectrometry and principal component analysis for the identification of coeluted substances in doping control analysis	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/S0378-4347(97)00559-8	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S0378-4347(97)00559-8	en
heal.language	English	en
heal.publicationDate	1998	en
heal.abstract	The identification of four doping control substances in an artificial mixture, using short column gas chromatography-mass spectrometry (CC-MS) analysis was examined. Two chromatographic peaks were recorded in the chromatogram, using a short capillary column (1.8 m) at an oven temperature of 180 degrees C. The first peak was associated with a mixture of a solvent derivative and an artifact. The second one corresponded to the mixture of four control substances. Principal component analysis was applied on a selected CC-Ms data set of the latter peak to determine clear full spectra of pure substances from mixture spectra. The time of GC-MS analysis was significantly reduced to less than 1 min from 30 min which is a typical GC-MS analysis time, using standard methods of doping control analysis. (C) 1998 Elsevier Science B.V.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Journal of Chromatography B: Biomedical Applications	en
dc.identifier.doi	10.1016/S0378-4347(97)00559-8	en
dc.identifier.isi	ISI:000072617900008	en
dc.identifier.volume	706	en
dc.identifier.issue	2	en
dc.identifier.spage	245	en
dc.identifier.epage	251	en