A 'pressure-time index' for assessing the severity of essential hypertension

Zakopoulos, NA; Toumanidis, ST; Barlas, GJ; Nanas, SN; Lekakis, JP; Stamatelopoulos, SF; Moulopoulos, SD

dc.contributor.author	Zakopoulos, NA	en
dc.contributor.author	Toumanidis, ST	en
dc.contributor.author	Barlas, GJ	en
dc.contributor.author	Nanas, SN	en
dc.contributor.author	Lekakis, JP	en
dc.contributor.author	Stamatelopoulos, SF	en
dc.contributor.author	Moulopoulos, SD	en
dc.date.accessioned	2014-03-01T01:14:20Z
dc.date.available	2014-03-01T01:14:20Z
dc.date.issued	1999	en
dc.identifier.issn	0263-6352	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13007
dc.subject	Ambulatory blood pressure	en
dc.subject	Area under the blood pressure curve	en
dc.subject	Blood pressure load	en
dc.subject	Hypertension	en
dc.subject	Left ventricular hypertrophy	en
dc.subject.classification	Peripheral Vascular Disease	en
dc.subject.other	adolescent	en
dc.subject.other	adult	en
dc.subject.other	age	en
dc.subject.other	aged	en
dc.subject.other	ambulatory monitoring	en
dc.subject.other	area under the curve	en
dc.subject.other	article	en
dc.subject.other	blood pressure measurement	en
dc.subject.other	blood pressure monitoring	en
dc.subject.other	circadian rhythm	en
dc.subject.other	clinical trial	en
dc.subject.other	diastolic blood pressure	en
dc.subject.other	disease severity	en
dc.subject.other	echocardiography	en
dc.subject.other	essential hypertension	en
dc.subject.other	female	en
dc.subject.other	heart left ventricle mass	en
dc.subject.other	human	en
dc.subject.other	major clinical study	en
dc.subject.other	male	en
dc.subject.other	multivariate analysis	en
dc.subject.other	priority journal	en
dc.subject.other	rating scale	en
dc.subject.other	systolic blood pressure	en
dc.subject.other	Adolescent	en
dc.subject.other	Adult	en
dc.subject.other	Aged	en
dc.subject.other	Blood Pressure	en
dc.subject.other	Blood Pressure Monitoring, Ambulatory	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Hypertension	en
dc.subject.other	Hypertrophy, Left Ventricular	en
dc.subject.other	Male	en
dc.subject.other	Middle Aged	en
dc.title	A 'pressure-time index' for assessing the severity of essential hypertension	en
heal.type	journalArticle	en
heal.identifier.primary	10.1097/00004872-199917100-00005	en
heal.identifier.secondary	http://dx.doi.org/10.1097/00004872-199917100-00005	en
heal.language	English	en
heal.publicationDate	1999	en
heal.abstract	Objective A new derivative of 24 h ambulatory blood pressure monitoring (ABPM) is introduced and its association with left ventricular mass index (LVMI) in essential hypertension is examined. Patient population One hundred and fifty-three previously untreated essential hypertension patients. Methods Patients underwent casual blood pressure (BP) readings, 24 h ABPM and left ventricular echocardiographic assessment The following 24 h awake and sleep ABP variables were calculated: mean systolic and diastolic BP, systolic and diastolic BP loads (percentage of systolic readings > 140/120 mmHg (day/night) and diastolic readings > 90/80 mmHg (day/night), standard deviation of systolic and diastolic ABP and nocturnal fall of systolic BP, as well as the integrated areas under the ABP curve. The area under the BP curve divided in horizontal slices was accurately modelled by a sigmoid curve. The parameters controlling the shape of the curve and in particular that regarding its 'slope' is hereafter called the 'pressure-time index'. Results 'Systolic pressure-time index 24 h' (SPTI24) is related to left ventricular mass index (multivariate analysis, P = 0.008). Using either partial correlation coefficients or a multivariate analysis, SPTI24 is related to left ventricular mass index, independently of age, casual blood pressure, mean systolic and diastolic ABP, systolic and diastolic BP loads, BP variability (standard deviation (SD), nocturnal fall of systolic BP) and integrated area under the curve (multivariate analysis, P = 0.004). Conclusions In essential hypertension, the SPTI24 is related to LVMI independently of age, casual blood pressure, integrated area under the curve or any other derivative of 24 h ABPM, and might be used to assess the extent of hypertensive load. J Hypertens 1999, 17:1387-1393 (C) Lippincott Williams & Wilkins.	en
heal.publisher	LIPPINCOTT WILLIAMS & WILKINS	en
heal.journalName	Journal of Hypertension	en
dc.identifier.doi	10.1097/00004872-199917100-00005	en
dc.identifier.isi	ISI:000083020200005	en
dc.identifier.volume	17	en
dc.identifier.issue	10	en
dc.identifier.spage	1387	en
dc.identifier.epage	1393	en