A tandem C-acylation-cyclization reaction sequence for the synthesis of new N-acyl-3-substituted 1,8-naphthyridine-2,4,diones

Zografos, A; Mitsos, C; Igglessi-Markopoulou, O

dc.contributor.author	Zografos, A	en
dc.contributor.author	Mitsos, C	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:14:22Z
dc.date.available	2014-03-01T01:14:22Z
dc.date.issued	1999	en
dc.identifier.issn	0385-5414	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13020
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0033166276&partnerID=40&md5=e20bac719349d9984c2fa543b8d12628	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	1,8 naphthyridine 2,4 dione	en
dc.subject.other	naphthyridinone	en
dc.subject.other	quinoline derivative	en
dc.subject.other	unclassified drug	en
dc.subject.other	acylation	en
dc.subject.other	allergic reaction	en
dc.subject.other	antibacterial activity	en
dc.subject.other	antiinflammatory activity	en
dc.subject.other	article	en
dc.subject.other	chemical reaction	en
dc.subject.other	drug potency	en
dc.subject.other	drug synthesis	en
dc.subject.other	mammal	en
dc.subject.other	receptor binding	en
dc.subject.other	stomach secretion	en
dc.title	A tandem C-acylation-cyclization reaction sequence for the synthesis of new N-acyl-3-substituted 1,8-naphthyridine-2,4,diones	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1999	en
heal.abstract	The 2-substituted 4H-pyrido[2,3-d][3,1]oxazin-4-ones (1a, b) react with active methylene compounds, under mild conditions, to produce N-acyl-3- substituted 1,8-naphthyridine-2,4-diones (3-12). In addition the C-acylation key intermediates (3a), (13) and (14) have been isolated and subsequently cyclized to the corresponding 3-substituted 1,8-naphthyridine-2,4-diones (3) and (15).	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Heterocycles	en
dc.identifier.isi	ISI:000081851600013	en
dc.identifier.volume	51	en
dc.identifier.issue	7	en
dc.identifier.spage	1609	en
dc.identifier.epage	1623	en