Anatomy-based three-dimensional dose optimization in brachytherapy using multiobjective genetic algorithms

Lahanas, M; Baltas, D; Zamboglou, N

dc.contributor.author	Lahanas, M	en
dc.contributor.author	Baltas, D	en
dc.contributor.author	Zamboglou, N	en
dc.date.accessioned	2014-03-01T01:14:24Z
dc.date.available	2014-03-01T01:14:24Z
dc.date.issued	1999	en
dc.identifier.issn	0094-2405	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13053
dc.subject	Brachytherapy	en
dc.subject	COIN	en
dc.subject	Dose-volume histograms	en
dc.subject	Multiobjective genetic algorithms	en
dc.subject	Optimization	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	algorithm	en
dc.subject.other	article	en
dc.subject.other	brachytherapy	en
dc.subject.other	dosimetry	en
dc.subject.other	implant	en
dc.subject.other	priority journal	en
dc.subject.other	radiation dose	en
dc.subject.other	radiation dose distribution	en
dc.subject.other	three dimensional imaging	en
dc.subject.other	Algorithms	en
dc.subject.other	Biophysics	en
dc.subject.other	Bone Neoplasms	en
dc.subject.other	Brachytherapy	en
dc.subject.other	Breast Neoplasms	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Models, Genetic	en
dc.subject.other	Models, Theoretical	en
dc.subject.other	Prostatic Neoplasms	en
dc.subject.other	Radiotherapy Planning, Computer-Assisted	en
dc.subject.other	Ribs	en
dc.subject.other	Software Design	en
dc.subject.other	Hypsophrys nicaraguensis	en
dc.title	Anatomy-based three-dimensional dose optimization in brachytherapy using multiobjective genetic algorithms	en
heal.type	journalArticle	en
heal.identifier.primary	10.1118/1.598697	en
heal.identifier.secondary	http://dx.doi.org/10.1118/1.598697	en
heal.language	English	en
heal.publicationDate	1999	en
heal.abstract	In conventional dose optimization algorithms, in brachytherapy, multiple objectives are expressed in terms of an aggregating function which combines individual objective values into a single utility value, making the problem single objective, prior to optimization. A multiobjective genetic algorithm (MOGA) was developed for dose optimization based on an a posteriori approach, leaving the decision-making process to a planner and offering a representative trade-off surface of the various objectives. The MOGA provides a flexible search engine which provides the maximum of information for a decision maker. Tests performed with various treatment plans in brachytherapy have shown that MOGA gives solutions which are superior to those of traditional dose optimization algorithms. Objectives were proposed in terms of the COW distribution and differential volume histograms, taking into account patient anatomy in the optimization process. (C) 1999 American Association of Physicists in Medicine. [S0094-2405(99)00309-0].	en
heal.publisher	AMER INST PHYSICS	en
heal.journalName	Medical Physics	en
dc.identifier.doi	10.1118/1.598697	en
dc.identifier.isi	ISI:000082632200022	en
dc.identifier.volume	26	en
dc.identifier.issue	9	en
dc.identifier.spage	1904	en
dc.identifier.epage	1918	en