Hydrogen-bonded complexes resulting from the interaction of alkylated barbituric acid and 2,6-diamidopyridine derivatives

Sideratou, Z; Tsiourvas, D; Paleos, CM; Peppas, E; Anastassopoulou, J; Theophanides, T

dc.contributor.author	Sideratou, Z	en
dc.contributor.author	Tsiourvas, D	en
dc.contributor.author	Paleos, CM	en
dc.contributor.author	Peppas, E	en
dc.contributor.author	Anastassopoulou, J	en
dc.contributor.author	Theophanides, T	en
dc.date.accessioned	2014-03-01T01:14:42Z
dc.date.available	2014-03-01T01:14:42Z
dc.date.issued	1999	en
dc.identifier.issn	0022-2860	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13195
dc.subject	Differential scanning calorimetry	en
dc.subject	FT-IR spectroscopy	en
dc.subject	Hydrogen bonding	en
dc.subject	Molecular recognition	en
dc.subject.classification	Chemistry, Physical	en
dc.subject.other	2,6 diaminopyridine	en
dc.subject.other	aminopyridine derivative	en
dc.subject.other	barbital	en
dc.subject.other	barbituric acid derivative	en
dc.subject.other	solvent	en
dc.subject.other	analytic method	en
dc.subject.other	article	en
dc.subject.other	chemical structure	en
dc.subject.other	complex formation	en
dc.subject.other	hydrogen bond	en
dc.subject.other	hydrophilicity	en
dc.subject.other	lipophilicity	en
dc.subject.other	molecular interaction	en
dc.subject.other	molecular recognition	en
dc.subject.other	phase transition	en
dc.subject.other	reaction analysis	en
dc.title	Hydrogen-bonded complexes resulting from the interaction of alkylated barbituric acid and 2,6-diamidopyridine derivatives	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/S0022-2860(98)00898-9	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S0022-2860(98)00898-9	en
heal.language	English	en
heal.publicationDate	1999	en
heal.abstract	In the present study a hydrophilic or a lipophilic alkylated barbituric acid derivative was allowed to interact in the melt and in solution with a complementary series of alkylated diamidopyridine derivatives, both hydrophilic or lipophilic. The interaction between the molecules was mainly studied by FT-IR spectroscopy. Phase transitions of reaction mixtures were studied with polarized optical microscopy and differential scanning calorimetry. It was found that the molecular recognition of the interacting components is only effective between the molecularly compatible ones. Specifically, employing Methods I and II, (see text) the short chain derivatives form 1:1 complexes whereas the long-chain derivatives are only partially complexed. Derivatives of dissimilar lipophilicity do not form complexes employing the same methods. However, comparing the two methods, complexation is more effective employing Method II. The induction of molecular recognition in the presence of an apolar solvent is enhanced in solution, Method III. The equilibrium which was established in solution is shifted to different directions during the evaporation step (Method II), leading either to the formation of complexes or to self-association. (C) 1999 Elsevier Science B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Journal of Molecular Structure	en
dc.identifier.doi	10.1016/S0022-2860(98)00898-9	en
dc.identifier.isi	ISI:000081044100009	en
dc.identifier.volume	484	en
dc.identifier.issue	1-3	en
dc.identifier.spage	91	en
dc.identifier.epage	101	en