Synthesis and properties of poly(lactic acid)

Andreopoulos, AG; Hatzi, E; Doxastakis, M

dc.contributor.author	Andreopoulos, AG	en
dc.contributor.author	Hatzi, E	en
dc.contributor.author	Doxastakis, M	en
dc.date.accessioned	2014-03-01T01:15:16Z
dc.date.available	2014-03-01T01:15:16Z
dc.date.issued	1999	en
dc.identifier.issn	0957-4530	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13403
dc.subject	Atmospheric Pressure	en
dc.subject	Controlled Release	en
dc.subject	High Molecular Weight	en
dc.subject	Lactic Acid	en
dc.subject	Molecular Weight	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	Atmospheric pressure	en
dc.subject.other	Biodegradation	en
dc.subject.other	Biosynthesis	en
dc.subject.other	Calorimetry	en
dc.subject.other	Hydrolysis	en
dc.subject.other	Molecular weight	en
dc.subject.other	Polyesters	en
dc.subject.other	Polymerization	en
dc.subject.other	Swelling	en
dc.subject.other	Vacuum applications	en
dc.subject.other	Viscosity measurement	en
dc.subject.other	Melting point	en
dc.subject.other	Polylactic acid	en
dc.subject.other	Biomaterials	en
dc.subject.other	lactic acid	en
dc.subject.other	polylactic acid	en
dc.subject.other	article	en
dc.subject.other	hydrolysis	en
dc.subject.other	melting point	en
dc.subject.other	molecular weight	en
dc.subject.other	polymerization	en
dc.subject.other	priority journal	en
dc.subject.other	vacuum	en
dc.subject.other	viscometry	en
dc.title	Synthesis and properties of poly(lactic acid)	en
heal.type	journalArticle	en
heal.identifier.primary	10.1023/A:1008887910068	en
heal.identifier.secondary	http://dx.doi.org/10.1023/A:1008887910068	en
heal.language	English	en
heal.publicationDate	1999	en
heal.abstract	Poly(D,L lactic acid) was prepared by bulk polymerization of D,L lactide, both under atmospheric pressure and in vacuum. The obtained polymeric products were characterized in terms of molecular weight, M(w), melting point, calorimetric response and swelling behaviour. All products were amorphous. Their molecular weights were determined by viscosimetry and ranged from 2 x 103 to 9 x 104. Similarly, the melting points ranged from 90 to 210°C. Swelling experiments, with specimens immersed in buffer solutions, showed that hydrolytic degradation started in a few days for the low M(w) material, whereas for the higher molecular weight products it took much longer and probably followed a two-stage mechanism. This study suggests that the high molecular weight material could be an interesting carrier for the preparation of controlled release products, in cases where prolonged delivery is necessary.Poly(D,L lactic acid) was prepared by bulk polymerization of D,L lactide, both under atmospheric pressure and in vacuum. The obtained polymeric products were characterized in terms of molecular weight, Mw, melting point, calorimetric response and swelling behaviour. All products were amorphous. Their molecular weights were determined by viscosimetry and ranged from 2×103 to 9×104. Similarly, the melting points ranged from 90 to 210 °C. Swelling experiments, with specimens immersed in buffer solutions, showed that hydrolytic degradation started in a few days for the low Mw material, whereas for the higher molecular weight products it took much longer and probably followed a two-stage mechanism. This study suggests that the high molecular weight material could be an interesting carrier for the preparation of controlled release products, in cases where prolonged delivery is necessary.	en
heal.publisher	Kluwer Academic Publishers, Dordrecht, Netherlands	en
heal.journalName	Journal of Materials Science: Materials in Medicine	en
dc.identifier.doi	10.1023/A:1008887910068	en
dc.identifier.isi	ISI:000079358600004	en
dc.identifier.volume	10	en
dc.identifier.issue	1	en
dc.identifier.spage	29	en
dc.identifier.epage	33	en