Synthesis of 3-substituted 4-hydroxyquinolin-2-ones via C-acylation reactions of active methylene compounds with functionalized 3,1-benzoxazin-4- ones

Mitsos, C; Zografos, A; Igglessi-Markopoulou, O

dc.contributor.author	Mitsos, C	en
dc.contributor.author	Zografos, A	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:15:16Z
dc.date.available	2014-03-01T01:15:16Z
dc.date.issued	1999	en
dc.identifier.issn	0385-5414	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13404
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0033165895&partnerID=40&md5=4c0700409cac0e4738aa578921d7b5ba	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	4 hydroxyquinolin 2 one	en
dc.subject.other	4h 3,1 benzoxazin 4 one derivative	en
dc.subject.other	DNA topoisomerase (ATP hydrolysing)	en
dc.subject.other	quinoline derivative	en
dc.subject.other	unclassified drug	en
dc.subject.other	acylation	en
dc.subject.other	antimicrobial activity	en
dc.subject.other	article	en
dc.subject.other	carbon nuclear magnetic resonance	en
dc.subject.other	chemical reaction	en
dc.subject.other	cytotoxicity	en
dc.subject.other	DNA replication	en
dc.subject.other	drug synthesis	en
dc.subject.other	human immunodeficiency virus 1	en
dc.subject.other	lipophilicity	en
dc.subject.other	proton nuclear magnetic resonance	en
dc.subject.other	structure activity relation	en
dc.title	Synthesis of 3-substituted 4-hydroxyquinolin-2-ones via C-acylation reactions of active methylene compounds with functionalized 3,1-benzoxazin-4- ones	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1999	en
heal.abstract	A general protocol for the construction of 4-hydroxyquinolin-2-ones is described. Benzoxazinones react with the anion of active methylene compounds to produce the functionalized C-acylation compounds in very good yields. These key intermediates are cyclized to the desired quinolinones (25-40) under basic conditions. Spectral data and physical characteristics for all compounds are reported.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Heterocycles	en
dc.identifier.isi	ISI:000081851600007	en
dc.identifier.volume	51	en
dc.identifier.issue	7	en
dc.identifier.spage	1543	en
dc.identifier.epage	1561	en