A study on structural and diffusion properties of porcine stratum corneum based on very small angle neutron scattering data

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dc.contributor.author Charalambopoulou, GC en
dc.contributor.author Karamertzanis, P en
dc.contributor.author Kikkinides, ES en
dc.contributor.author Stubos, AK en
dc.contributor.author Kanellopoulos, NK en
dc.contributor.author Papaioannou, AT en
dc.date.accessioned 2014-03-01T01:15:27Z
dc.date.available 2014-03-01T01:15:27Z
dc.date.issued 2000 en
dc.identifier.issn 0724-8741 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/13509
dc.subject stratum corneum en
dc.subject structural characteristics en
dc.subject diffusion en
dc.subject neutron scattering en
dc.subject.classification Chemistry, Multidisciplinary en
dc.subject.classification Pharmacology & Pharmacy en
dc.subject.other X-RAY-DIFFRACTION en
dc.subject.other DRUG PERMEATION en
dc.subject.other MODEL en
dc.subject.other MEDIA en
dc.title A study on structural and diffusion properties of porcine stratum corneum based on very small angle neutron scattering data en
heal.type journalArticle en
heal.identifier.primary 10.1023/A:1026453628800 en
heal.identifier.secondary http://dx.doi.org/10.1023/A:1026453628800 en
heal.language English en
heal.publicationDate 2000 en
heal.abstract Purpose. Generation of valuable information about the biphasic geometrical configuration of porcine stratum corneum from Very Small Angle Neutron Scattering (VSANS) data and investigation of its effect on the corresponding effective diffusivity. Methods, Spectra of porcine stratum corneum are mathematically transformed in order to obtain the: corresponding auto-correlation function (ACF). Model stratum corneum structures, matching this experimentally determined ACF, are then produced based on the "brick-and-mortar" configuration. The effective diffusivity through these model domains is calculated using an appropriate numerical method. Results, The most appropriate geometry of porcine stratum corneum's lipid and protein phases in a "brick-and-mortar" configuration is quantitatively determined and correlated with the barrier properties (diffusivity) of the stratum corneum model structures. Conclusions. The ACF analysis indicates the most appropriate values for the dimensions of the corneocyte thickness and the surrounding lipid gap, while the corneocyte length is estimated from the diffusion study. en
dc.identifier.doi 10.1023/A:1026453628800 en
dc.identifier.isi ISI:000090147600007 en
dc.identifier.volume 17 en
dc.identifier.issue 9 en
dc.identifier.spage 1085 en
dc.identifier.epage 1091 en

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