A study on structural and diffusion properties of porcine stratum corneum based on very small angle neutron scattering data

Charalambopoulou, GC; Karamertzanis, P; Kikkinides, ES; Stubos, AK; Kanellopoulos, NK; Papaioannou, AT

dc.contributor.author	Charalambopoulou, GC	en
dc.contributor.author	Karamertzanis, P	en
dc.contributor.author	Kikkinides, ES	en
dc.contributor.author	Stubos, AK	en
dc.contributor.author	Kanellopoulos, NK	en
dc.contributor.author	Papaioannou, AT	en
dc.date.accessioned	2014-03-01T01:15:27Z
dc.date.available	2014-03-01T01:15:27Z
dc.date.issued	2000	en
dc.identifier.issn	0724-8741	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13509
dc.subject	stratum corneum	en
dc.subject	structural characteristics	en
dc.subject	diffusion	en
dc.subject	neutron scattering	en
dc.subject.classification	Chemistry, Multidisciplinary	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.other	X-RAY-DIFFRACTION	en
dc.subject.other	PERCUTANEOUS ABSORPTION	en
dc.subject.other	DRUG PERMEATION	en
dc.subject.other	MODEL	en
dc.subject.other	MEDIA	en
dc.title	A study on structural and diffusion properties of porcine stratum corneum based on very small angle neutron scattering data	en
heal.type	journalArticle	en
heal.identifier.primary	10.1023/A:1026453628800	en
heal.identifier.secondary	http://dx.doi.org/10.1023/A:1026453628800	en
heal.language	English	en
heal.publicationDate	2000	en
heal.abstract	Purpose. Generation of valuable information about the biphasic geometrical configuration of porcine stratum corneum from Very Small Angle Neutron Scattering (VSANS) data and investigation of its effect on the corresponding effective diffusivity. Methods, Spectra of porcine stratum corneum are mathematically transformed in order to obtain the: corresponding auto-correlation function (ACF). Model stratum corneum structures, matching this experimentally determined ACF, are then produced based on the "brick-and-mortar" configuration. The effective diffusivity through these model domains is calculated using an appropriate numerical method. Results, The most appropriate geometry of porcine stratum corneum's lipid and protein phases in a "brick-and-mortar" configuration is quantitatively determined and correlated with the barrier properties (diffusivity) of the stratum corneum model structures. Conclusions. The ACF analysis indicates the most appropriate values for the dimensions of the corneocyte thickness and the surrounding lipid gap, while the corneocyte length is estimated from the diffusion study.	en
heal.publisher	KLUWER ACADEMIC/PLENUM PUBL	en
heal.journalName	PHARMACEUTICAL RESEARCH	en
dc.identifier.doi	10.1023/A:1026453628800	en
dc.identifier.isi	ISI:000090147600007	en
dc.identifier.volume	17	en
dc.identifier.issue	9	en
dc.identifier.spage	1085	en
dc.identifier.epage	1091	en