Controlled release systems based on poly(lactic acid). An in vitro and in vivo study

Andreopoulos, AG; Hatzi, EC; Doxastakis, M

dc.contributor.author	Andreopoulos, AG	en
dc.contributor.author	Hatzi, EC	en
dc.contributor.author	Doxastakis, M	en
dc.date.accessioned	2014-03-01T01:15:31Z
dc.date.available	2014-03-01T01:15:31Z
dc.date.issued	2000	en
dc.identifier.issn	0957-4530	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13564
dc.subject	Controlled Release	en
dc.subject	Delivery System	en
dc.subject	In Vitro Release	en
dc.subject	Minimum Inhibitory Concentration	en
dc.subject	Lactic Acid	en
dc.subject	Low Molecular Weight	en
dc.subject	Poly Lactic Acid	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	POLY(DL-LACTIDE)	en
dc.subject.other	POLYLACTONES	en
dc.title	Controlled release systems based on poly(lactic acid). An in vitro and in vivo study	en
heal.type	journalArticle	en
heal.identifier.primary	10.1023/A:1008990109419	en
heal.identifier.secondary	http://dx.doi.org/10.1023/A:1008990109419	en
heal.language	English	en
heal.publicationDate	2000	en
heal.abstract	A new biodegradable delivery system based on poly(lactic acid) has been formulated, with potential applications in sustained antibiotic release against bone infection. The in vitro release of a new quinolone (pefloxacin) from low molecular weight poly(D,L-lactic acid) (Mw = 2 x 10(3)) lasted for 56 d whereas the in vivo delivery lasted 33 d. In both cases, the release rate is controlled by the drug diffusion and the polymer degradation, which seems to be the predominant factor. For the release experiments, discs were prepared from poly (D,L-lactide) (Mw = 2 x 10(4)) with drug loadings of 2% and 10% w/w. It was concluded that pefloxacin concentration remains higher than the Minimum Inhibitory Concentration (MIC) against the major causative bacteria of bone infection. The results indicate that the two different types of poly(lactic acid) can be used effectively in an implantable antibiotic release system. (C) 2000 Kluwer Academic Publishers.	en
heal.publisher	KLUWER ACADEMIC PUBL	en
heal.journalName	JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE	en
dc.identifier.doi	10.1023/A:1008990109419	en
dc.identifier.isi	ISI:000087371700009	en
dc.identifier.volume	11	en
dc.identifier.issue	6	en
dc.identifier.spage	393	en
dc.identifier.epage	397	en