Development of a fluorescence-based imaging system for colon cancer diagnosis using two novel rhodamine derivatives

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dc.contributor.author Yova, D en
dc.contributor.author Atlamazoglou, V en
dc.contributor.author Kavantzas, N en
dc.contributor.author Loukas, S en
dc.date.accessioned 2014-03-01T01:15:32Z
dc.date.available 2014-03-01T01:15:32Z
dc.date.issued 2000 en
dc.identifier.issn 0268-8921 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/13576
dc.subject colon cancer en
dc.subject fluorescence imaging en
dc.subject optical biopsy en
dc.subject rhodamine derivatives en
dc.subject.classification Engineering, Biomedical en
dc.subject.classification Surgery en
dc.subject.other TISSUE DIAGNOSTICS en
dc.subject.other MITOCHONDRIA en
dc.subject.other SPECTROSCOPY en
dc.subject.other SCATTERING en
dc.subject.other CARCINOMA en
dc.subject.other MUCOSA en
dc.subject.other CELLS en
dc.subject.other RAT en
dc.title Development of a fluorescence-based imaging system for colon cancer diagnosis using two novel rhodamine derivatives en
heal.type journalArticle en
heal.identifier.primary 10.1007/s101030050059 en
heal.identifier.secondary http://dx.doi.org/10.1007/s101030050059 en
heal.language English en
heal.publicationDate 2000 en
heal.abstract Tissue characterisation by endoscopic fluorescence imaging of exogenous fluorophores appears to be a promising method for cancer detection. Cationic and lipophilic fluorescence compounds of the aminoxanthene chemical family, have been found to exhibit selective accumulation in various carcinoma cells. In this paper the development of an endoscopic fluorescence-based imaging system with the additional capability of collecting emission spectra is described, which was used with two novel fluorescent probes rhodamine B-leucine amide and rhodamine B-phenyl boronic acid, for colon cancer diagnosis, in ex vivo tissue samples. Fluorescence images of human colon tissue revealed a remarkable differentiation of cancerous, from healthy colonic mucosa, confirmed by histopathology studies. These results from fluorescence imaging of colonic tissue were in total correspondence with the information extracted from the collection of fluorescence spectra. en
dc.identifier.doi 10.1007/s101030050059 en
dc.identifier.isi ISI:000087233700008 en
dc.identifier.volume 15 en
dc.identifier.issue 2 en
dc.identifier.spage 140 en
dc.identifier.epage 147 en

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