Development of a fluorescence-based imaging system for colon cancer diagnosis using two novel rhodamine derivatives

Yova, D; Atlamazoglou, V; Kavantzas, N; Loukas, S

dc.contributor.author	Yova, D	en
dc.contributor.author	Atlamazoglou, V	en
dc.contributor.author	Kavantzas, N	en
dc.contributor.author	Loukas, S	en
dc.date.accessioned	2014-03-01T01:15:32Z
dc.date.available	2014-03-01T01:15:32Z
dc.date.issued	2000	en
dc.identifier.issn	0268-8921	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13576
dc.subject	colon cancer	en
dc.subject	fluorescence imaging	en
dc.subject	optical biopsy	en
dc.subject	rhodamine derivatives	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Surgery	en
dc.subject.other	TISSUE DIAGNOSTICS	en
dc.subject.other	MITOCHONDRIA	en
dc.subject.other	SPECTROSCOPY	en
dc.subject.other	SCATTERING	en
dc.subject.other	CARCINOMA	en
dc.subject.other	MUCOSA	en
dc.subject.other	CELLS	en
dc.subject.other	RAT	en
dc.title	Development of a fluorescence-based imaging system for colon cancer diagnosis using two novel rhodamine derivatives	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/s101030050059	en
heal.identifier.secondary	http://dx.doi.org/10.1007/s101030050059	en
heal.language	English	en
heal.publicationDate	2000	en
heal.abstract	Tissue characterisation by endoscopic fluorescence imaging of exogenous fluorophores appears to be a promising method for cancer detection. Cationic and lipophilic fluorescence compounds of the aminoxanthene chemical family, have been found to exhibit selective accumulation in various carcinoma cells. In this paper the development of an endoscopic fluorescence-based imaging system with the additional capability of collecting emission spectra is described, which was used with two novel fluorescent probes rhodamine B-leucine amide and rhodamine B-phenyl boronic acid, for colon cancer diagnosis, in ex vivo tissue samples. Fluorescence images of human colon tissue revealed a remarkable differentiation of cancerous, from healthy colonic mucosa, confirmed by histopathology studies. These results from fluorescence imaging of colonic tissue were in total correspondence with the information extracted from the collection of fluorescence spectra.	en
heal.publisher	SPRINGER-VERLAG LONDON LTD	en
heal.journalName	LASERS IN MEDICAL SCIENCE	en
dc.identifier.doi	10.1007/s101030050059	en
dc.identifier.isi	ISI:000087233700008	en
dc.identifier.volume	15	en
dc.identifier.issue	2	en
dc.identifier.spage	140	en
dc.identifier.epage	147	en