Generation of uniformly distributed dose points for anatomy-based three-dimensional dose optimization methods in brachytherapy

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dc.contributor.author Lahanas, M en
dc.contributor.author Baltas, D en
dc.contributor.author Giannouli, S en
dc.contributor.author Milickovic, N en
dc.contributor.author Zamboglou, N en
dc.date.accessioned 2014-03-01T01:15:37Z
dc.date.available 2014-03-01T01:15:37Z
dc.date.issued 2000 en
dc.identifier.issn 0094-2405 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/13630
dc.subject dose distributions en
dc.subject dose optimization en
dc.subject sampling point distribution en
dc.subject quasi-random en
dc.subject brachytherapy en
dc.subject.classification Radiology, Nuclear Medicine & Medical Imaging en
dc.subject.other I-125 PROSTATE IMPLANTS en
dc.subject.other GENETIC ALGORITHM en
dc.subject.other SPECIFICATION en
dc.title Generation of uniformly distributed dose points for anatomy-based three-dimensional dose optimization methods in brachytherapy en
heal.type journalArticle en
heal.identifier.primary 10.1118/1.598970 en
heal.identifier.secondary http://dx.doi.org/10.1118/1.598970 en
heal.language English en
heal.publicationDate 2000 en
heal.abstract We have studied the accuracy of statistical parameters of dose distributions in brachytherapy using actual clinical implants. These include the mean, minimum and maximum dose values and the variance of the dose distribution inside the PTV (planning target volume), and on the surface of the PTV. These properties have been studied as a function of the number of uniformly distributed sampling points. These parameters, or the variants of these parameters, are used directly or indirectly in optimization procedures or for a description of the dose distribution. The accurate determination of these parameters depends on the sampling point distribution from which they have been obtained. Some optimization methods ignore catheters and critical structures surrounded by the PTV or alternatively consider as surface dose points only those on the contour lines of the PTV. D-min and D-max are extreme dose values which are either on the PTV surface or within the PTV. They must be avoided for specification and optimization purposes in brachytherapy. Using D-mean and the variance of D which we have shown to be stable parameters, achieves a more reliable description of the dose distribution on the PTV surface and within the PTV volume than does D-min, and D,,. Generation of dose points on the real surface of the PTV is obligatory and the consideration of catheter volumes results in a realistic description of anatomical dose distributions. (C) 2000 American Association of Physicists in Medicine. [S0094-2405(00)01105-6]. en
heal.publisher AMER INST PHYSICS en
heal.journalName MEDICAL PHYSICS en
dc.identifier.doi 10.1118/1.598970 en
dc.identifier.isi ISI:000087212200026 en
dc.identifier.volume 27 en
dc.identifier.issue 5 en
dc.identifier.spage 1034 en
dc.identifier.epage 1046 en

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