Generation of uniformly distributed dose points for anatomy-based three-dimensional dose optimization methods in brachytherapy

Lahanas, M; Baltas, D; Giannouli, S; Milickovic, N; Zamboglou, N

dc.contributor.author	Lahanas, M	en
dc.contributor.author	Baltas, D	en
dc.contributor.author	Giannouli, S	en
dc.contributor.author	Milickovic, N	en
dc.contributor.author	Zamboglou, N	en
dc.date.accessioned	2014-03-01T01:15:37Z
dc.date.available	2014-03-01T01:15:37Z
dc.date.issued	2000	en
dc.identifier.issn	0094-2405	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13630
dc.subject	dose distributions	en
dc.subject	dose optimization	en
dc.subject	sampling point distribution	en
dc.subject	quasi-random	en
dc.subject	brachytherapy	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	I-125 PROSTATE IMPLANTS	en
dc.subject.other	GENETIC ALGORITHM	en
dc.subject.other	SPECIFICATION	en
dc.title	Generation of uniformly distributed dose points for anatomy-based three-dimensional dose optimization methods in brachytherapy	en
heal.type	journalArticle	en
heal.identifier.primary	10.1118/1.598970	en
heal.identifier.secondary	http://dx.doi.org/10.1118/1.598970	en
heal.language	English	en
heal.publicationDate	2000	en
heal.abstract	We have studied the accuracy of statistical parameters of dose distributions in brachytherapy using actual clinical implants. These include the mean, minimum and maximum dose values and the variance of the dose distribution inside the PTV (planning target volume), and on the surface of the PTV. These properties have been studied as a function of the number of uniformly distributed sampling points. These parameters, or the variants of these parameters, are used directly or indirectly in optimization procedures or for a description of the dose distribution. The accurate determination of these parameters depends on the sampling point distribution from which they have been obtained. Some optimization methods ignore catheters and critical structures surrounded by the PTV or alternatively consider as surface dose points only those on the contour lines of the PTV. D-min and D-max are extreme dose values which are either on the PTV surface or within the PTV. They must be avoided for specification and optimization purposes in brachytherapy. Using D-mean and the variance of D which we have shown to be stable parameters, achieves a more reliable description of the dose distribution on the PTV surface and within the PTV volume than does D-min, and D,,. Generation of dose points on the real surface of the PTV is obligatory and the consideration of catheter volumes results in a realistic description of anatomical dose distributions. (C) 2000 American Association of Physicists in Medicine. [S0094-2405(00)01105-6].	en
heal.publisher	AMER INST PHYSICS	en
heal.journalName	MEDICAL PHYSICS	en
dc.identifier.doi	10.1118/1.598970	en
dc.identifier.isi	ISI:000087212200026	en
dc.identifier.volume	27	en
dc.identifier.issue	5	en
dc.identifier.spage	1034	en
dc.identifier.epage	1046	en