Psychophysiological evaluation of short-term neurotoxicity after prophylactic brain irradiation in patients with small cell lung cancer: a study of event related potentials

Parageorgiou, C; Dardoufas, C; Kouloulias, V; Ventouras, E; Uzunoglu, N; Vlahos, L; Rambavilas, A; Christodoulou, G

dc.contributor.author	Parageorgiou, C	en
dc.contributor.author	Dardoufas, C	en
dc.contributor.author	Kouloulias, V	en
dc.contributor.author	Ventouras, E	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Vlahos, L	en
dc.contributor.author	Rambavilas, A	en
dc.contributor.author	Christodoulou, G	en
dc.date.accessioned	2014-03-01T01:15:50Z
dc.date.available	2014-03-01T01:15:50Z
dc.date.issued	2000	en
dc.identifier.issn	0167-594X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13758
dc.subject	prophylactic cranial irradiation (PCI)	en
dc.subject	small cell lung cancer (SCLC)	en
dc.subject	event related potentials (ERPs)	en
dc.subject	psychopsysiological	en
dc.subject	neurotoxicity	en
dc.subject.classification	Oncology	en
dc.subject.classification	Clinical Neurology	en
dc.subject.other	ACUTE LYMPHOBLASTIC-LEUKEMIA	en
dc.subject.other	RATING DEPRESSION SCALE	en
dc.subject.other	CRANIAL IRRADIATION	en
dc.subject.other	FOLLOW-UP	en
dc.subject.other	EVOKED-POTENTIALS	en
dc.subject.other	RADIATION-THERAPY	en
dc.subject.other	SURVIVORS	en
dc.subject.other	CARCINOMA	en
dc.subject.other	ABNORMALITIES	en
dc.subject.other	CHEMOTHERAPY	en
dc.title	Psychophysiological evaluation of short-term neurotoxicity after prophylactic brain irradiation in patients with small cell lung cancer: a study of event related potentials	en
heal.type	journalArticle	en
heal.identifier.primary	10.1023/A:1006447624574	en
heal.identifier.secondary	http://dx.doi.org/10.1023/A:1006447624574	en
heal.language	English	en
heal.publicationDate	2000	en
heal.abstract	Background. The aim of this study was to show, whether a certain prophylacting applicable radiation affects the cognition, particularly, the specific cognitive components P50, N100, P300 and N400 of auditory event related potentials (ERPs) during a short memory test. Methods and materials. Eleven patients with small cell lung cancer (SCLC), who had presented complete response of disease after chemotherapy and radical radiotherapy in the lung, were prescribed to receive a prophylacting cranial irradiation (PCI) with a 6 MeV linear accelerator. The dose schedule was consisting of a total dose up to 30 Gy in 10 fractions, within 12 days (5 days a week). The psychophysiological approach before and after PCI was assessed by measurements of the auditory ERPs during a short memory performance using the digit-span Wechsler test. Components of ERP were recorded from 15 scalp electrodes. Additionally, symptomatology of depression and anxiety were assessed using Zung Self-Rating Depression Scale and Spielberger Anxiety Inventory, respectively, for pre- and post-PCI. Results. No significant difference was noticed pre- and post-radiotherapy of all particular level of psychophysiological analysis concerning both the latencies and the amplitudes of ERPs auditory components P50, N100, P300 and N400 (P > 0.05, Wilcoxon signed test). Additionally, no changes were found with regard to behavioral performance (memory recall), depression symptomatology and state anxiety, according to pre- and post-radiation measurements. However, the self-reported depression symptomatology showed that the patients presented moderate depression. Conclusion. No short-term psychophysiological neurotoxicity was detected with this PCI schedule using these instruments, lending additional support to evidence suggesting the benefit of this certain PCI schedule for patients with SCLC.	en
heal.publisher	KLUWER ACADEMIC PUBL	en
heal.journalName	JOURNAL OF NEURO-ONCOLOGY	en
dc.identifier.doi	10.1023/A:1006447624574	en
dc.identifier.isi	ISI:000166774000009	en
dc.identifier.volume	50	en
dc.identifier.issue	3	en
dc.identifier.spage	275	en
dc.identifier.epage	285	en