Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test

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dc.contributor.author Papageorgiou, C en
dc.contributor.author Liappas, I en
dc.contributor.author Asvestas, P en
dc.contributor.author Vasios, C en
dc.contributor.author Matsopoulos, GK en
dc.contributor.author Nikolaou, C en
dc.contributor.author Nikita, KS en
dc.contributor.author Uzunoglu, N en
dc.contributor.author Rabavilas, A en
dc.date.accessioned 2014-03-01T01:16:05Z
dc.date.available 2014-03-01T01:16:05Z
dc.date.issued 2001 en
dc.identifier.issn 0959-4965 en
dc.identifier.uri http://hdl.handle.net/123456789/13913
dc.subject Abstinence en
dc.subject Event-related potentials en
dc.subject Heroin addiction en
dc.subject P600 en
dc.subject Working memory en
dc.subject.classification Neurosciences en
dc.subject.other diamorphine en
dc.subject.other adult en
dc.subject.other article en
dc.subject.other brain function en
dc.subject.other clinical article en
dc.subject.other cognition en
dc.subject.other controlled study en
dc.subject.other drug withdrawal en
dc.subject.other event related potential en
dc.subject.other female en
dc.subject.other heroin dependence en
dc.subject.other human en
dc.subject.other male en
dc.subject.other priority journal en
dc.subject.other psychologic test en
dc.subject.other right hemisphere en
dc.subject.other working memory en
dc.subject.other Adult en
dc.subject.other Brain en
dc.subject.other Evoked Potentials en
dc.subject.other Female en
dc.subject.other Heroin en
dc.subject.other Heroin Dependence en
dc.subject.other Humans en
dc.subject.other Male en
dc.subject.other Memory en
dc.subject.other Reference Values en
dc.subject.other Substance Withdrawal Syndrome en
dc.subject.other Time Factors en
dc.title Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test en
heal.type journalArticle en
heal.identifier.primary 10.1097/00001756-200106130-00051 en
heal.identifier.secondary http://dx.doi.org/10.1097/00001756-200106130-00051 en
heal.language English en
heal.publicationDate 2001 en
heal.abstract The P600 component of event-related potentials, believed to be generated by anterior cingulate gyrus and basal ganglia, is considered as an index of aspects of second-pass parsing processes of information processing, having much in common with working memory (WM) systems. Moreover, dysfunction of these brain structures as well as WM deficits have been implicated in the pathophysiology of opioid addicts. The present study is focused on P600 elicited during a WM test in twenty heroin addicts with prolonged abstinence compared with an equal number of healthy controls. The results showed significantly prolonged latencies at right hemisphere, specifically at F rho2 abduction. Moreover, memory performance of patients did not differ from that of normal controls. These findings may indicate that abstinent heroin addicts manifest abnormal aspects of second-pass parsing processes as are reflected by the P600 latencies, elicited during a WM test. Additionally, the P600 might serve as a valuable investigative tool for a more comprehensive understanding of the neurobiological substrate of drug abuse. NeuroReport 12:1773-1778 (C) 2001 Lippincott Williams & Wilkins. en
heal.journalName NeuroReport en
dc.identifier.doi 10.1097/00001756-200106130-00051 en
dc.identifier.isi ISI:000169185400047 en
dc.identifier.volume 12 en
dc.identifier.issue 8 en
dc.identifier.spage 1773 en
dc.identifier.epage 1778 en

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