Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test

Papageorgiou, C; Liappas, I; Asvestas, P; Vasios, C; Matsopoulos, GK; Nikolaou, C; Nikita, KS; Uzunoglu, N; Rabavilas, A

dc.contributor.author	Papageorgiou, C	en
dc.contributor.author	Liappas, I	en
dc.contributor.author	Asvestas, P	en
dc.contributor.author	Vasios, C	en
dc.contributor.author	Matsopoulos, GK	en
dc.contributor.author	Nikolaou, C	en
dc.contributor.author	Nikita, KS	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Rabavilas, A	en
dc.date.accessioned	2014-03-01T01:16:05Z
dc.date.available	2014-03-01T01:16:05Z
dc.date.issued	2001	en
dc.identifier.issn	0959-4965	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13913
dc.subject	Abstinence	en
dc.subject	Event-related potentials	en
dc.subject	Heroin addiction	en
dc.subject	P600	en
dc.subject	Working memory	en
dc.subject.classification	Neurosciences	en
dc.subject.other	diamorphine	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	brain function	en
dc.subject.other	clinical article	en
dc.subject.other	cognition	en
dc.subject.other	controlled study	en
dc.subject.other	drug withdrawal	en
dc.subject.other	event related potential	en
dc.subject.other	female	en
dc.subject.other	heroin dependence	en
dc.subject.other	human	en
dc.subject.other	male	en
dc.subject.other	priority journal	en
dc.subject.other	psychologic test	en
dc.subject.other	right hemisphere	en
dc.subject.other	working memory	en
dc.subject.other	Adult	en
dc.subject.other	Brain	en
dc.subject.other	Evoked Potentials	en
dc.subject.other	Female	en
dc.subject.other	Heroin	en
dc.subject.other	Heroin Dependence	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Memory	en
dc.subject.other	Reference Values	en
dc.subject.other	Substance Withdrawal Syndrome	en
dc.subject.other	Time Factors	en
dc.title	Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test	en
heal.type	journalArticle	en
heal.identifier.primary	10.1097/00001756-200106130-00051	en
heal.identifier.secondary	http://dx.doi.org/10.1097/00001756-200106130-00051	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	The P600 component of event-related potentials, believed to be generated by anterior cingulate gyrus and basal ganglia, is considered as an index of aspects of second-pass parsing processes of information processing, having much in common with working memory (WM) systems. Moreover, dysfunction of these brain structures as well as WM deficits have been implicated in the pathophysiology of opioid addicts. The present study is focused on P600 elicited during a WM test in twenty heroin addicts with prolonged abstinence compared with an equal number of healthy controls. The results showed significantly prolonged latencies at right hemisphere, specifically at F rho2 abduction. Moreover, memory performance of patients did not differ from that of normal controls. These findings may indicate that abstinent heroin addicts manifest abnormal aspects of second-pass parsing processes as are reflected by the P600 latencies, elicited during a WM test. Additionally, the P600 might serve as a valuable investigative tool for a more comprehensive understanding of the neurobiological substrate of drug abuse. NeuroReport 12:1773-1778 (C) 2001 Lippincott Williams & Wilkins.	en
heal.publisher	LIPPINCOTT WILLIAMS & WILKINS	en
heal.journalName	NeuroReport	en
dc.identifier.doi	10.1097/00001756-200106130-00051	en
dc.identifier.isi	ISI:000169185400047	en
dc.identifier.volume	12	en
dc.identifier.issue	8	en
dc.identifier.spage	1773	en
dc.identifier.epage	1778	en