Beta versus gamma dosimetry close to Ir-192 brachytherapy sources

Baltas, D; Karaiskos, P; Papagiannis, P; Sakelliou, L; Loeffler, E; Zamboglou, N

dc.contributor.author	Baltas, D	en
dc.contributor.author	Karaiskos, P	en
dc.contributor.author	Papagiannis, P	en
dc.contributor.author	Sakelliou, L	en
dc.contributor.author	Loeffler, E	en
dc.contributor.author	Zamboglou, N	en
dc.date.accessioned	2014-03-01T01:16:11Z
dc.date.available	2014-03-01T01:16:11Z
dc.date.issued	2001	en
dc.identifier.issn	0094-2405	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13969
dc.subject	192Ir, Monte Carlo simulation	en
dc.subject	Beta particles	en
dc.subject	Dosimetry	en
dc.subject	Endobronchial brachytherapy	en
dc.subject	Intravascular brachytherapy	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	iridium 192	en
dc.subject.other	article	en
dc.subject.other	beta radiation	en
dc.subject.other	blood vessel diameter	en
dc.subject.other	brachytherapy	en
dc.subject.other	clinical practice	en
dc.subject.other	dose calculation	en
dc.subject.other	dosimetry	en
dc.subject.other	encapsulation	en
dc.subject.other	gamma radiation	en
dc.subject.other	priority journal	en
dc.subject.other	radiation dose	en
dc.subject.other	simulation	en
dc.subject.other	Beta Rays	en
dc.subject.other	Biophysics	en
dc.subject.other	Brachytherapy	en
dc.subject.other	Coronary Restenosis	en
dc.subject.other	Coronary Vessels	en
dc.subject.other	Gamma Rays	en
dc.subject.other	Humans	en
dc.subject.other	Iridium Radioisotopes	en
dc.subject.other	Monte Carlo Method	en
dc.subject.other	Radiotherapy Dosage	en
dc.subject.other	Radiotherapy Planning, Computer-Assisted	en
dc.title	Beta versus gamma dosimetry close to Ir-192 brachytherapy sources	en
heal.type	journalArticle	en
heal.identifier.primary	10.1118/1.1395038	en
heal.identifier.secondary	http://dx.doi.org/10.1118/1.1395038	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	The relative importance of the dose rate component owing to the beta spectrum emitted by Ir-192 brachytherapy sources at the short radial distances of interest in intravascular and endobronchial applications is investigated. Separate dosimetric calculations, using Monte Carlo simulations, were performed for the gamma and beta dose rate components of an Ir-192 ideal point source as weld as real Ir-192 source designs used in clinical practice including wire and seed sources and both Nucletron and Varian, old and new, high dose rate (HDR) source designs. A significant dose rate enhancement due to the beta spectrum emitted by Ir-192, greater than 50% for radial distances r < 2 mm, was observed for an ideal point source. For real source designs, however, the magnitude of this enhancement was found to depend strongly on the sources' geometric as well as compositional details of the active core and encapsulation. A detectable effect was found for the majority of the investigated sources at radial distances less than I nim, but overall findings suggest that the contribution of beta particles is not significant in Ir-192 clinical intravascular applications that are currently carried out. However, since treatment of vessels with smaller diameters, in the future, may lead to the development of Ir-192 sources and catheters of reduced diameters, the potential effect of the beta spectrum in terms of dose enhancement to tissues in close proximity to Ir-192 sources should not be ignored. (C) 2001 American Association of Physicists in Medicine.	en
heal.publisher	AMER INST PHYSICS	en
heal.journalName	Medical Physics	en
dc.identifier.doi	10.1118/1.1395038	en
dc.identifier.isi	ISI:000171175300005	en
dc.identifier.volume	28	en
dc.identifier.issue	9	en
dc.identifier.spage	1875	en
dc.identifier.epage	1882	en