Controlled release of salicylic acid from poly(D,L-Lactide)

Andreopoulos, AG; Hatzi, E; Doxastakis, M

dc.contributor.author	Andreopoulos, AG	en
dc.contributor.author	Hatzi, E	en
dc.contributor.author	Doxastakis, M	en
dc.date.accessioned	2014-03-01T01:16:15Z
dc.date.available	2014-03-01T01:16:15Z
dc.date.issued	2001	en
dc.identifier.issn	0957-4530	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/13998
dc.subject	Controlled Release	en
dc.subject	Salicylic Acid	en
dc.subject	High Molecular Weight	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	buffer	en
dc.subject.other	polylactide	en
dc.subject.other	salicylic acid	en
dc.subject.other	acidity	en
dc.subject.other	article	en
dc.subject.other	biodegradation	en
dc.subject.other	controlled drug release	en
dc.subject.other	linear system	en
dc.subject.other	melting point	en
dc.subject.other	molecular size	en
dc.subject.other	molecular weight	en
dc.subject.other	polymerization	en
dc.subject.other	priority journal	en
dc.title	Controlled release of salicylic acid from poly(D,L-Lactide)	en
heal.type	journalArticle	en
heal.identifier.primary	10.1023/A:1008911131657	en
heal.identifier.secondary	http://dx.doi.org/10.1023/A:1008911131657	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	Poly(D,L-Lactide) of high molecular weight (M-v) was prepared by ring-opening bulk polymerization of D,L-Lactide and characterized in terms of M-v, melting point and swelling behavior in buffer solution. Samples of the polymers with low and high M (v) (2000 and 22 000 respectively) loaded with various amounts of salicylic acid (SA) were immersed in a buffer solution and the release of SA was recorded. The results obtained showed that swelling of the poly(D,L-Lactide) samples obeyed Fick's law, especially for those with high molecular weight, where biodegradation proceeds slowly. The release of SA seemed to follow a simplified relationship which is linear with time, at least for the early stages of delivery. The extent of linearity is dependent on the content of the acidic SA, which probably accelerates decomposition of the high molecular weight products. (C) 2001 Kluwer Academic Publishers.	en
heal.publisher	KLUWER ACADEMIC PUBL	en
heal.journalName	Journal of Materials Science: Materials in Medicine	en
dc.identifier.doi	10.1023/A:1008911131657	en
dc.identifier.isi	ISI:000167045100007	en
dc.identifier.volume	12	en
dc.identifier.issue	3	en
dc.identifier.spage	233	en
dc.identifier.epage	239	en