Impaired P600 in neuroleptic naive patients with first-episode schizophrenia

Papageorgiou, C; Kontaxakis, VP; Havaki-Kontaxaki, BJ; Stamouli, S; Vasios, C; Asvestas, P; Matsopoulos, GK; Kontopantelis, E; Rabavilas, A; Uzunoglu, N; Christodoulou, GN

dc.contributor.author	Papageorgiou, C	en
dc.contributor.author	Kontaxakis, VP	en
dc.contributor.author	Havaki-Kontaxaki, BJ	en
dc.contributor.author	Stamouli, S	en
dc.contributor.author	Vasios, C	en
dc.contributor.author	Asvestas, P	en
dc.contributor.author	Matsopoulos, GK	en
dc.contributor.author	Kontopantelis, E	en
dc.contributor.author	Rabavilas, A	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Christodoulou, GN	en
dc.date.accessioned	2014-03-01T01:16:38Z
dc.date.available	2014-03-01T01:16:38Z
dc.date.issued	2001	en
dc.identifier.issn	0959-4965	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14134
dc.subject	Event-related potentials	en
dc.subject	First-episode schizophrenia	en
dc.subject	P600	en
dc.subject	Working memory	en
dc.subject.classification	Neurosciences	en
dc.subject.other	neuroleptic agent	en
dc.subject.other	adult	en
dc.subject.other	amplitude modulation	en
dc.subject.other	article	en
dc.subject.other	clinical article	en
dc.subject.other	controlled study	en
dc.subject.other	event related potential	en
dc.subject.other	female	en
dc.subject.other	human	en
dc.subject.other	information processing	en
dc.subject.other	male	en
dc.subject.other	memory	en
dc.subject.other	occipital cortex	en
dc.subject.other	priority journal	en
dc.subject.other	schizophrenia	en
dc.subject.other	working memory	en
dc.subject.other	Acoustic Stimulation	en
dc.subject.other	Adult	en
dc.subject.other	Age of Onset	en
dc.subject.other	Antipsychotic Agents	en
dc.subject.other	Cerebral Cortex	en
dc.subject.other	Chronic Disease	en
dc.subject.other	Electroencephalography	en
dc.subject.other	Evoked Potentials	en
dc.subject.other	Female	en
dc.subject.other	Hospitalization	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Memory Disorders	en
dc.subject.other	Memory, Short-Term	en
dc.subject.other	Neuropsychological Tests	en
dc.subject.other	Predictive Value of Tests	en
dc.subject.other	Reaction Time	en
dc.subject.other	Schizophrenia	en
dc.subject.other	Statistical Distributions	en
dc.title	Impaired P600 in neuroleptic naive patients with first-episode schizophrenia	en
heal.type	journalArticle	en
heal.identifier.primary	10.1097/00001756-200109170-00010	en
heal.identifier.secondary	http://dx.doi.org/10.1097/00001756-200109170-00010	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 elicited during a WM test in drug-naive first-episode schizophrenics (FES) compared to healthy controls. We examined 16 drug-naive first-episode schizophrenic patients and 23 healthy controls matched for age and sex. Compared with controls schizophrenic patients showed reduced P600 amplitude on left temporoparietal region and increased P600 amplitude on left occipital region. With regard to the latency, the patients exhibited significantly prolongation on right temporoparietal region. The obtained pattern of differences classified correctly 89.20% of patients. Memory performance of patients was also significantly impaired relative to controls. Our results suggest that second-pass parsing process of information processing, as indexed by P600, elicited during a WM test, is impaired in FES. Moreover, these findings lend support to the view that the auditory WM in schizophrenia involves or affects a circuitry including temporoparietal and occipital brain areas. NeuroReport 12:2801-2806 (C) 2001 Lippincott Williams & Wilkins.	en
heal.publisher	LIPPINCOTT WILLIAMS & WILKINS	en
heal.journalName	NeuroReport	en
dc.identifier.doi	10.1097/00001756-200109170-00010	en
dc.identifier.isi	ISI:000171161700005	en
dc.identifier.volume	12	en
dc.identifier.issue	13	en
dc.identifier.spage	2801	en
dc.identifier.epage	2806	en