Is external palliative radiotherapy for gallbladder carcinoma effective?

Eleftheriadis, N; Pistevou-Gombaki, K; Plataniotis, G; Sofroniadis, I; Kouloulias, V

dc.contributor.author	Eleftheriadis, N	en
dc.contributor.author	Pistevou-Gombaki, K	en
dc.contributor.author	Plataniotis, G	en
dc.contributor.author	Sofroniadis, I	en
dc.contributor.author	Kouloulias, V	en
dc.date.accessioned	2014-03-01T01:16:39Z
dc.date.available	2014-03-01T01:16:39Z
dc.date.issued	2001	en
dc.identifier.issn	0378-584X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14154
dc.subject	External radiotherapy	en
dc.subject	Gallbladder cancer	en
dc.subject	Palliation	en
dc.subject.classification	Oncology	en
dc.subject.other	cobalt 60	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	bile duct prosthesis	en
dc.subject.other	cancer palliative therapy	en
dc.subject.other	cancer radiotherapy	en
dc.subject.other	cancer regression	en
dc.subject.other	cancer staging	en
dc.subject.other	case report	en
dc.subject.other	computer assisted tomography	en
dc.subject.other	disease course	en
dc.subject.other	female	en
dc.subject.other	follow up	en
dc.subject.other	gallbladder carcinoma	en
dc.subject.other	hospital discharge	en
dc.subject.other	human	en
dc.subject.other	percutaneous transhepatic drainage	en
dc.subject.other	radiation dose	en
dc.subject.other	treatment outcome	en
dc.subject.other	tumor localization	en
dc.subject.other	Cobalt Radioisotopes	en
dc.subject.other	Female	en
dc.subject.other	Follow-Up Studies	en
dc.subject.other	Gallbladder Neoplasms	en
dc.subject.other	Humans	en
dc.subject.other	Middle Aged	en
dc.subject.other	Neoplasm Staging	en
dc.subject.other	Palliative Care	en
dc.subject.other	Radioisotope Teletherapy	en
dc.subject.other	Radiotherapy Planning, Computer-Assisted	en
dc.subject.other	Tomography, X-Ray Computed	en
dc.title	Is external palliative radiotherapy for gallbladder carcinoma effective?	en
heal.type	journalArticle	en
heal.identifier.primary	10.1159/000055147	en
heal.identifier.secondary	http://dx.doi.org/10.1159/000055147	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	Background: Gallbladder carcinoma is characterized by delayed diagnosis, ineffective treatment and poor prognosis. Surgical resection has been thought to be the treatment of choice, while the role of radiotherapy as adjuvant or palliative treatment has not been fully clarified in the literature. Patient and Methods: We present the case of a 45-year-old female, with unresectable gallbladder carcinoma, grade IV, histologically diagnosed during laparotomy. The patient was treated with palliative intent with percutaneous transhepatic biliary drainage. Furthermore, she received external radiotherapy by Co-60, using a three-field technique (anterior-posterior and right lateral). The total dose was 3,000 cGy in 10 fractions, with 300 cGy per fraction, 5 days weekly. Results: The patient showed clinico-laboratory improvement and was discharged with a permanent percutaneous transhepatic endoprosthesis. During follow-up (10 and 12 months postirradiation), abdominal CTs showed no local extension of the tumor, while the patient had a good performance status. So far, 1 year after the diagnosis of gallbladder cancer she is still alive. Conclusions: External radiotherapy seems to be a safe and effective method of palliative management of gallbladder carcinoma. However, further studies are necessary to determine the role of radiotherapy in palliative or adjuvant treatment of gallbladder carcinoma.	en
heal.publisher	KARGER	en
heal.journalName	Onkologie	en
dc.identifier.doi	10.1159/000055147	en
dc.identifier.isi	ISI:000173599200009	en
dc.identifier.volume	24	en
dc.identifier.issue	6	en
dc.identifier.spage	581	en
dc.identifier.epage	584	en