Numerical and experimental investigation of the diffusional release of a dispersed solute from polymeric multilaminate matrices

Charalambopoulou, GCh; Kikkinides, ES; Papadokostaki, KG; Stubos, AK; Papaioannou, ATh

dc.contributor.author	Charalambopoulou, GCh	en
dc.contributor.author	Kikkinides, ES	en
dc.contributor.author	Papadokostaki, KG	en
dc.contributor.author	Stubos, AK	en
dc.contributor.author	Papaioannou, ATh	en
dc.date.accessioned	2014-03-01T01:16:49Z
dc.date.available	2014-03-01T01:16:49Z
dc.date.issued	2001	en
dc.identifier.issn	0168-3659	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14238
dc.subject	Controlled release	en
dc.subject	Mathematical modeling	en
dc.subject	Multilaminates	en
dc.subject	Zero-order release	en
dc.subject.classification	Chemistry, Multidisciplinary	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.other	cellulose acetate	en
dc.subject.other	polymer	en
dc.subject.other	article	en
dc.subject.other	controlled release formulation	en
dc.subject.other	diffusion coefficient	en
dc.subject.other	drug delivery system	en
dc.subject.other	drug diffusion	en
dc.subject.other	drug distribution	en
dc.subject.other	drug release	en
dc.subject.other	experimentation	en
dc.subject.other	intermethod comparison	en
dc.subject.other	mathematical model	en
dc.subject.other	priority journal	en
dc.subject.other	sustained drug release	en
dc.subject.other	thermodynamics	en
dc.subject.other	Diffusion	en
dc.subject.other	Drug Delivery Systems	en
dc.subject.other	Mathematics	en
dc.subject.other	Models, Theoretical	en
dc.subject.other	Polymers	en
dc.title	Numerical and experimental investigation of the diffusional release of a dispersed solute from polymeric multilaminate matrices	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/S0168-3659(00)00357-6	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S0168-3659(00)00357-6	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	In the present work the release behavior of special, multilaminate matrix-type polymer systems, is studied both theoretically and experimentally. Two different mathematical models have been employed to describe the release of a dispersed solute from both single- and multilayer matrices. A parameter sensitivity study shows that the incorporation of supersaturated matrices in the formation of multilaminate devices, with a nonuniform initial solute loading, can provide a delivery system with optimized performance compared to monolithic ones. Finally, the findings of this theoretical analysis show,good agreement with measurements of the release rates of a model disperse dye from both single- and multilayer matrices. (C) 2001 Published by Elsevier Science B.V.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Journal of Controlled Release	en
dc.identifier.doi	10.1016/S0168-3659(00)00357-6	en
dc.identifier.isi	ISI:000167379700005	en
dc.identifier.volume	70	en
dc.identifier.issue	3	en
dc.identifier.spage	309	en
dc.identifier.epage	319	en