Regioselective acylation of flavonoids catalyzed by lipase in low toxicity media

Kontogianni, A; Skouridou, V; Sereti, V; Stamatis, H; Kolisis, FN

dc.contributor.author	Kontogianni, A	en
dc.contributor.author	Skouridou, V	en
dc.contributor.author	Sereti, V	en
dc.contributor.author	Stamatis, H	en
dc.contributor.author	Kolisis, FN	en
dc.date.accessioned	2014-03-01T01:17:00Z
dc.date.available	2014-03-01T01:17:00Z
dc.date.issued	2001	en
dc.identifier.issn	1438-7697	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14320
dc.subject	Acylation	en
dc.subject	Flavonoids	en
dc.subject	Lipase	en
dc.subject	Naringin	en
dc.subject	Organic solvents	en
dc.subject	Rutin	en
dc.subject.classification	Food Science & Technology	en
dc.subject.classification	Nutrition & Dietetics	en
dc.subject.other	SOLID-PHASE SYNTHESIS	en
dc.subject.other	ENZYMATIC-SYNTHESIS	en
dc.subject.other	CANDIDA-ANTARCTICA	en
dc.subject.other	NATURAL COMPOUNDS	en
dc.subject.other	ORGANIC-SOLVENTS	en
dc.subject.other	WATER ACTIVITY	en
dc.subject.other	MONOGLYCOSIDES	en
dc.subject.other	ANTIOXIDANTS	en
dc.subject.other	DERIVATIVES	en
dc.subject.other	GLUCOSIDE	en
dc.title	Regioselective acylation of flavonoids catalyzed by lipase in low toxicity media	en
heal.type	journalArticle	en
heal.identifier.primary	10.1002/1438-9312(200110)103:10<655::AID-EJLT655>3.3.CO;2-O	en
heal.identifier.secondary	http://dx.doi.org/10.1002/1438-9312(200110)103:10<655::AID-EJLT655>3.3.CO;2-O	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	Flavonoid fatty esters were prepared by acylation of flavonoids (rutin and naringin) by fatty acids (C8, C10, C12), catalyzed by immobilized lipase from Candida antarctica in various solvent systems. The reaction parameters affecting the conversion of the enzymatic process, such as the nature of the organic solvent and acyl donor used, the water activity (a(w)) of the system, as well as the acyl donor concentration have been investigated. At optimum reaction conditions, the conversion of flavonoids was 50-60% in tert-butanol at a(w) less than 0.11. In all cases studied, only flavonoid monoester was identified, which indicates that this lipase-catalyzed esterification is regioselective.	en
heal.publisher	WILEY-V C H VERLAG GMBH	en
heal.journalName	European Journal of Lipid Science and Technology	en
dc.identifier.doi	10.1002/1438-9312(200110)103:10<655::AID-EJLT655>3.3.CO;2-O	en
dc.identifier.isi	ISI:000171803700003	en
dc.identifier.volume	103	en
dc.identifier.issue	10	en
dc.identifier.spage	655	en
dc.identifier.epage	660	en