Spectroscopic characterisation of carotid atherosclerotic plaque by laser induced fluorescence

Anastassopoulou, N; Arapoglou, B; Demakakos, P; Makropoulou, MI; Paphiti, A; Serafetinides, AA

dc.contributor.author	Anastassopoulou, N	en
dc.contributor.author	Arapoglou, B	en
dc.contributor.author	Demakakos, P	en
dc.contributor.author	Makropoulou, MI	en
dc.contributor.author	Paphiti, A	en
dc.contributor.author	Serafetinides, AA	en
dc.date.accessioned	2014-03-01T01:17:08Z
dc.date.available	2014-03-01T01:17:08Z
dc.date.issued	2001	en
dc.identifier.issn	0196-8092	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14367
dc.subject	Laser biomedical applications	en
dc.subject	Optical spectroscopy	en
dc.subject.classification	Surgery	en
dc.subject.other	argon laser	en
dc.subject.other	article	en
dc.subject.other	atherosclerosis	en
dc.subject.other	atherosclerotic plaque	en
dc.subject.other	carotid artery obstruction	en
dc.subject.other	carotid endarterectomy	en
dc.subject.other	diagnostic accuracy	en
dc.subject.other	fluorescence	en
dc.subject.other	human	en
dc.subject.other	human tissue	en
dc.subject.other	krypton laser	en
dc.subject.other	laser	en
dc.subject.other	priority journal	en
dc.subject.other	pulsed dye laser	en
dc.subject.other	spectral sensitivity	en
dc.subject.other	Carotid Arteries	en
dc.subject.other	Carotid Artery Diseases	en
dc.subject.other	Humans	en
dc.subject.other	Intracranial Arteriosclerosis	en
dc.subject.other	Lasers	en
dc.subject.other	Microscopy, Fluorescence	en
dc.title	Spectroscopic characterisation of carotid atherosclerotic plaque by laser induced fluorescence	en
heal.type	journalArticle	en
heal.identifier.primary	10.1002/1096-9101(2001)28:1<67::AID-LSM1018>3.0.CO;2-E	en
heal.identifier.secondary	http://dx.doi.org/10.1002/1096-9101(2001)28:1<67::AID-LSM1018>3.0.CO;2-E	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	Background and Objective: An effort has been made to distinguish the composition of carotid atherosclerotic plaques (CAP) from patients undergoing carotid endarterectomy, by laser induced fluorescence spectroscopy. Study Design/Materials and Methods: Different excitation wavelengths were used: 476, 488, and 458 nm of a continuous wave krypton/argon ion laser, and 337 nm of a pulsed nitrogen laser. Twenty-three CAP samples from different patients were investigated and several spectra from each plaque were obtained. Results: Results were crossed-examined with conventional histologic techniques, which showed three areas of different composition on the pathologic samples: fibrous tissue, lipid constituents, and calcified plaque. Gaussian fittings were performed to reproduce the fluorescence spectra as a correlation of multiple Gaussian curves. Conclusion: The accuracy for discrimination of the heterogeneous composition of the atherosclerotic plaque is still limited, due to superposition of the fluorescence emission of various plaque components. Lasers Surg. Med. 28: 67-73, 2001. (C) 2001 Wiley-Liss, Inc.	en
heal.publisher	WILEY-LISS	en
heal.journalName	Lasers in Surgery and Medicine	en
dc.identifier.doi	10.1002/1096-9101(2001)28:1<67::AID-LSM1018>3.0.CO;2-E	en
dc.identifier.isi	ISI:000166206900010	en
dc.identifier.volume	28	en
dc.identifier.issue	1	en
dc.identifier.spage	67	en
dc.identifier.epage	73	en