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Swelling properties of various polymers used in controlled release systems

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dc.contributor.author Vlachou, M en
dc.contributor.author Naseef, H en
dc.contributor.author Efentakis, M en
dc.contributor.author Tarantili, PA en
dc.contributor.author Andreopoulos, AG en
dc.date.accessioned 2014-03-01T01:17:12Z
dc.date.available 2014-03-01T01:17:12Z
dc.date.issued 2001 en
dc.identifier.issn 0885-3282 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/14388
dc.subject Controlled release en
dc.subject Diffusion en
dc.subject Porosity en
dc.subject Power packing en
dc.subject Swelling en
dc.subject.classification Engineering, Biomedical en
dc.subject.classification Materials Science, Biomaterials en
dc.subject.other Degradation en
dc.subject.other Dissolution en
dc.subject.other Hydrolysis en
dc.subject.other Porosity en
dc.subject.other Solubility en
dc.subject.other Swelling en
dc.subject.other Acid hydrolysis en
dc.subject.other Controlled release systems en
dc.subject.other Polymers en
dc.subject.other polymer en
dc.subject.other article en
dc.subject.other chemistry en
dc.subject.other drug delivery system en
dc.subject.other hydrolysis en
dc.subject.other solubility en
dc.subject.other Drug Delivery Systems en
dc.subject.other Hydrolysis en
dc.subject.other Polymers en
dc.subject.other Solubility en
dc.title Swelling properties of various polymers used in controlled release systems en
heal.type journalArticle en
heal.identifier.primary 10.1106/RJ4E-95LE-46BT-PUK0 en
heal.identifier.secondary http://dx.doi.org/10.1106/RJ4E-95LE-46BT-PUK0 en
heal.language English en
heal.publicationDate 2001 en
heal.abstract The effect of powder packing and porosity of specimens on the swelling properties of polymeric materials was studied, in various swelling liquids, such as distilled water and 0.1 N hydrochloric acid solution. Capsules, tablets and films of hydroxypropyl methylcellulose, poly(ethylene oxide) and sodium alginate were prepared and their weight uptake after immersion into the above solutions was recorded as a function of time, in order to assess the swelling process. Measurements of some characteristics of the as received powders were also performed as an attempt to classify the specimens prepared according to their porosity. Within the experimental conditions of this work, it was shown that the porosity of polymeric specimens is a dominant factor that controls their swelling behaviour. Increased porosity leads to fast initial rates of weight uptake and high extent of equilibrium swelling. On the other hand, dissolution and possible degradation of polymers susceptible to acid hydrolysis, results in some variations from the above-mentioned behaviour. With respect to the application in controlled release systems, the overall delivery rate from a polymeric specimen is expected to be a function of both swelling and disintegration characteristics of a specimen and, therefore, the weight uptake can be considered a measure of the release only in the case of polymers with low water solubility and increased stability to hydrolysis. en
heal.publisher SAGE PUBLICATIONS LTD en
heal.journalName Journal of Biomaterials Applications en
dc.identifier.doi 10.1106/RJ4E-95LE-46BT-PUK0 en
dc.identifier.isi ISI:000173045100003 en
dc.identifier.volume 16 en
dc.identifier.issue 2 en
dc.identifier.spage 125 en
dc.identifier.epage 138 en


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