Synthesis and NMR spectroscopic studies of optically active derivatives of γ-aminobutenoic acids and 2-amino-pyrrolin-4-ones

Petroliagi, M; Igglessi-Markopoulou, O

dc.contributor.author	Petroliagi, M	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:17:12Z
dc.date.available	2014-03-01T01:17:12Z
dc.date.issued	2001	en
dc.identifier.issn	0022152X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14391
dc.subject	Optical Activity	en
dc.subject.other	alpha amino acid	en
dc.subject.other	antiretrovirus agent	en
dc.subject.other	ethyl 4 acetylamino 2 cyano 3 hydroxy 5 methylhex 2 enoate	en
dc.subject.other	ethyl 4 acetylamino 2 cyano 3 hydroxy 5 phenylpent 2 enoate	en
dc.subject.other	ethyl 4 acetylamino 2 cyano 3 hydroxy 6 methyl 2 heptanoate	en
dc.subject.other	ethyl 4 acetylamino 2 cyano 3 hydroxypent 2 enoate	en
dc.subject.other	gamma aminobutenoic acid	en
dc.subject.other	unclassified drug	en
dc.subject.other	article	en
dc.subject.other	cyclization	en
dc.subject.other	drug synthesis	en
dc.subject.other	high performance liquid chromatography	en
dc.subject.other	nuclear magnetic resonance spectroscopy	en
dc.subject.other	optical rotation	en
dc.subject.other	reaction analysis	en
dc.title	Synthesis and NMR spectroscopic studies of optically active derivatives of γ-aminobutenoic acids and 2-amino-pyrrolin-4-ones	en
heal.type	journalArticle	en
heal.identifier.primary	10.1002/jhet.5570380416	en
heal.identifier.secondary	http://dx.doi.org/10.1002/jhet.5570380416	en
heal.publicationDate	2001	en
heal.abstract	An efficient method for the preparation of optically active derivatives of γ-amino-butenoic acids and their cyclic derivatives, 2-amino-pyrrolin-4-ones, from α-amino acids is described. Partial racemization accompanies the formation of initial unsaturated γ-amino-β-hydroxy esters 5-8, as determined by chiral HPLC.	en
heal.journalName	Journal of Heterocyclic Chemistry	en
dc.identifier.doi	10.1002/jhet.5570380416	en
dc.identifier.volume	38	en
dc.identifier.issue	4	en
dc.identifier.spage	917	en
dc.identifier.epage	922	en