Xanthan gum as a carrier for controlled release of drugs

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dc.contributor.author Andreopoulos, AG en
dc.contributor.author Tarantili, PA en
dc.date.accessioned 2014-03-01T01:17:19Z
dc.date.available 2014-03-01T01:17:19Z
dc.date.issued 2001 en
dc.identifier.issn 0885-3282 en
dc.identifier.uri http://hdl.handle.net/123456789/14459
dc.subject Biopolymers en
dc.subject Controlled release en
dc.subject Polymeric drug carriers en
dc.subject Salicylic acid en
dc.subject Swelling en
dc.subject Xanthan gum en
dc.subject.classification Engineering, Biomedical en
dc.subject.classification Materials Science, Biomaterials en
dc.subject.other Drug products en
dc.subject.other Organic acids en
dc.subject.other Pharmacodynamics en
dc.subject.other Solutions en
dc.subject.other Sorption en
dc.subject.other Swelling en
dc.subject.other Water en
dc.subject.other Controlled release en
dc.subject.other Non Frickian transport en
dc.subject.other Polymeric drug carrier en
dc.subject.other Salicylic acid en
dc.subject.other Xanthan gum matrix en
dc.subject.other Biopolymers en
dc.subject.other bacterial polysaccharide en
dc.subject.other drug carrier en
dc.subject.other salicylic acid en
dc.subject.other xanthan en
dc.subject.other article en
dc.subject.other tablet en
dc.subject.other Drug Carriers en
dc.subject.other Polysaccharides, Bacterial en
dc.subject.other Salicylic Acid en
dc.subject.other Tablets en
dc.title Xanthan gum as a carrier for controlled release of drugs en
heal.type journalArticle en
heal.identifier.primary 10.1106/XBFG-FYFX-9TW9-M83U en
heal.identifier.secondary http://dx.doi.org/10.1106/XBFG-FYFX-9TW9-M83U en
heal.language English en
heal.publicationDate 2001 en
heal.abstract Systems based on xanthan gum matrix containing 1%, 2% and 5% salicylic acid were prepared and studied as controlled release devices. Swelling of the matrix in distilled water and buffer solutions showed that the ionic strength of the liquid has a strong effect on the sorptive properties of the matrix. From the release experiments, conducted in distilled water at 37 +/-0.5 degreesC, it was found that the drug delivery process was accomplished within the first 10 hours after immersion and salicylic acid was always released via a non-Fickian transport. The phenomenon can be described by a release exponent (n) in the area of 0.77 independently of the initial concentration of salicylic acid in the xanthan matrix. These results can be interpreted taking into consideration the dimensional and physical changes of the polymeric matrix during swelling. en
heal.publisher TECHNOMIC PUBL CO INC en
heal.journalName Journal of Biomaterials Applications en
dc.identifier.doi 10.1106/XBFG-FYFX-9TW9-M83U en
dc.identifier.isi ISI:000169733400003 en
dc.identifier.volume 16 en
dc.identifier.issue 1 en
dc.identifier.spage 34 en
dc.identifier.epage 46 en

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