Xanthan gum as a carrier for controlled release of drugs

Andreopoulos, AG; Tarantili, PA

dc.contributor.author	Andreopoulos, AG	en
dc.contributor.author	Tarantili, PA	en
dc.date.accessioned	2014-03-01T01:17:19Z
dc.date.available	2014-03-01T01:17:19Z
dc.date.issued	2001	en
dc.identifier.issn	0885-3282	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14459
dc.subject	Biopolymers	en
dc.subject	Controlled release	en
dc.subject	Polymeric drug carriers	en
dc.subject	Salicylic acid	en
dc.subject	Swelling	en
dc.subject	Xanthan gum	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	Drug products	en
dc.subject.other	Organic acids	en
dc.subject.other	Pharmacodynamics	en
dc.subject.other	Solutions	en
dc.subject.other	Sorption	en
dc.subject.other	Swelling	en
dc.subject.other	Water	en
dc.subject.other	Controlled release	en
dc.subject.other	Non Frickian transport	en
dc.subject.other	Polymeric drug carrier	en
dc.subject.other	Salicylic acid	en
dc.subject.other	Xanthan gum matrix	en
dc.subject.other	Biopolymers	en
dc.subject.other	bacterial polysaccharide	en
dc.subject.other	drug carrier	en
dc.subject.other	salicylic acid	en
dc.subject.other	xanthan	en
dc.subject.other	article	en
dc.subject.other	tablet	en
dc.subject.other	Drug Carriers	en
dc.subject.other	Polysaccharides, Bacterial	en
dc.subject.other	Salicylic Acid	en
dc.subject.other	Tablets	en
dc.title	Xanthan gum as a carrier for controlled release of drugs	en
heal.type	journalArticle	en
heal.identifier.primary	10.1106/XBFG-FYFX-9TW9-M83U	en
heal.identifier.secondary	http://dx.doi.org/10.1106/XBFG-FYFX-9TW9-M83U	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	Systems based on xanthan gum matrix containing 1%, 2% and 5% salicylic acid were prepared and studied as controlled release devices. Swelling of the matrix in distilled water and buffer solutions showed that the ionic strength of the liquid has a strong effect on the sorptive properties of the matrix. From the release experiments, conducted in distilled water at 37 +/-0.5 degreesC, it was found that the drug delivery process was accomplished within the first 10 hours after immersion and salicylic acid was always released via a non-Fickian transport. The phenomenon can be described by a release exponent (n) in the area of 0.77 independently of the initial concentration of salicylic acid in the xanthan matrix. These results can be interpreted taking into consideration the dimensional and physical changes of the polymeric matrix during swelling.	en
heal.publisher	TECHNOMIC PUBL CO INC	en
heal.journalName	Journal of Biomaterials Applications	en
dc.identifier.doi	10.1106/XBFG-FYFX-9TW9-M83U	en
dc.identifier.isi	ISI:000169733400003	en
dc.identifier.volume	16	en
dc.identifier.issue	1	en
dc.identifier.spage	34	en
dc.identifier.epage	46	en