Detection of CD55- and/or CD59-deficient red cell populations in patients with plasma cell dyscrasias

Meletis, J; Terpos, E; Samarkos, M; Meletis, C; Apostolidou, E; Komninaka, V; Korovesis, K; Anargyrou, K; Benopoulou, O; Mavrogianni, D; Variami, E; Viniou, N; Konstantopoulos, K

dc.contributor.author	Meletis, J	en
dc.contributor.author	Terpos, E	en
dc.contributor.author	Samarkos, M	en
dc.contributor.author	Meletis, C	en
dc.contributor.author	Apostolidou, E	en
dc.contributor.author	Komninaka, V	en
dc.contributor.author	Korovesis, K	en
dc.contributor.author	Anargyrou, K	en
dc.contributor.author	Benopoulou, O	en
dc.contributor.author	Mavrogianni, D	en
dc.contributor.author	Variami, E	en
dc.contributor.author	Viniou, N	en
dc.contributor.author	Konstantopoulos, K	en
dc.date.accessioned	2014-03-01T01:17:41Z
dc.date.available	2014-03-01T01:17:41Z
dc.date.issued	2002	en
dc.identifier.issn	0925-5710	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14627
dc.subject	CD55	en
dc.subject	CD59	en
dc.subject	Multiple myeloma	en
dc.subject	Paroxysmal nocturnal hemoglobinuria	en
dc.subject	Waldenström macroglobulinemia	en
dc.subject.classification	Hematology	en
dc.subject.other	CD59 antigen	en
dc.subject.other	decay accelerating factor	en
dc.subject.other	article	en
dc.subject.other	erythrocyte	en
dc.subject.other	heavy chain disease	en
dc.subject.other	human	en
dc.subject.other	monoclonal immunoglobulinemia	en
dc.subject.other	multiple myeloma	en
dc.subject.other	paroxysmal nocturnal hemoglobinuria	en
dc.subject.other	plasma cell dyscrasia	en
dc.subject.other	Waldenstroem macroglobulinemia	en
dc.title	Detection of CD55- and/or CD59-deficient red cell populations in patients with plasma cell dyscrasias	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/BF02981977	en
heal.identifier.secondary	http://dx.doi.org/10.1007/BF02981977	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder characterized by a decrease or absence of glycosylphosphatidylinositol (GPI)-anchored molecules such as CD55 and CD59 from the surface of affected cells. resulting in intravascular hemolysis. cytopenia, and venous thrombosis. A PNH-like phenotype has been detected in various hematological disorders, mainly in aplastic anemia and myelodysplastic syndromes, but also in lymphoproliferative syndromes (LPSs). To the best of our knowledge. CD55- or CD59-deficient red cells have not been detected in Plasma cell dyscrasias (PCDs). The aim of this study was the detection of CD55- and/or CD59-deficient red cell populations in patients with PCD. Seventy-seven patients were evaluated; 62 with multiple myeloma (MM), 7 with Waldenstrom macroglobulinemia (WM), 6 with monoclonal gammopathy of undetermined significance (MGUS), and 2 with heavy chain disease (HCD). The sephacryl gel microtyping system was applied: Ham and sucrose lysis tests were also performed on all samples with CD55- or CD59-negative populations. Red cells deficient in both molecules were detected in 10 (12.9%) of 77 patients with PCD: 2 (28.6%) of 7 with WM, 1 (16.6%) of 6 with MGUS, 6 (9.6%) of 62 with MM, and 1 of 2 patients with HCD. Isolated CD55 deficiency was found in 28.5% of all PCD patients. whereas isolated CD59 deficiency was not observed in any patients. These findings illustrate the existence of the PNH phenotype in the red cells of patients with PCD: further investigation is needed into the mechanisms and significance of this phenotype. Int J Hematol. 2002;75:40-44. (C) 2002 The Japanese Society of Hematology.	en
heal.publisher	CARDEN JENNINGS PUBL CO LTD	en
heal.journalName	International Journal of Hematology	en
dc.identifier.doi	10.1007/BF02981977	en
dc.identifier.isi	ISI:000173702100007	en
dc.identifier.volume	75	en
dc.identifier.issue	1	en
dc.identifier.spage	40	en
dc.identifier.epage	44	en